Antigen-specific in vitro immunization: A source for human monoclonal antibodies

Kosuke Tomimatsu, Sanetaka Shirahata

研究成果: Chapter in Book/Report/Conference proceedingChapter

1 被引用数 (Scopus)

抄録

Human monoclonal antibody has great potential for treatment of various diseases utilizing their specificity against antigens. We have shown an in vitro immunization (IVI) protocol inducing antigen-specific immune responses in human peripheral blood mononuclear cells (PBMCs) for efficient production of human monoclonal antibodies. By using IVI method antigen specific antibody genes can be efficiently obtained because of increasing production of antigen-specific antibodies from in vitro immunized PBMCs. This IVI protocol will be widely applied for combination with several display methods and enhance the production of human monoclonal antibodies.

本文言語英語
ホスト出版物のタイトルHuman Monoclonal Antibodies
ホスト出版物のサブタイトルMethods and Protocols
出版社Humana Press Inc.
ページ297-307
ページ数11
ISBN(印刷版)9781627035859
DOI
出版ステータス出版済み - 2014

出版物シリーズ

名前Methods in Molecular Biology
1060
ISSN(印刷版)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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