Antigen-specific suppressor T lymphocytes (Leu-2a+3a-) in human Schistosomiasis japonica

N. Ohta, M. Minai, T. Sasazuki

研究成果: Contribution to journalArticle査読

19 被引用数 (Scopus)

抄録

Immunoregulatory mechanisms in human schistosomiasis japonica were investigated through in vitro T lymphocyte-macrophage co-culture experiments. High responder T lymphocytes responded to the schistosomal adult worm antigen in the presence of HLA-DR-compatible low responder macrophages, whereas low responder T lymphocytes failed to respond to this antigen even in the presence of HLA-DR-compatible high responder macrophages. This observation strongly suggested that T lymphocytes, but not macrophages, controlled the low responsiveness to the schistosomal adult worm antigen. When high responder lymphocytes were challenged with the schistosomal antigen in the presence of low responder T lymphocytes, low responder T lymphocytes caused an antigen-specific suppression, in a dose-dependent manner, of the responsiveness of high responder lymphocytes. The suppressor T lymphocytes were mitomycin C resistant and were positive for Leu-2a, but were negative for Leu-3a. When Leu-2a+ T lymphocytes were depleted from low responder T lymphocytes, a vigorous response by the Leu-2a-depleted T lymphocytes (Leu-2a-3a+) to the schistosomal adult worm antigen was observed. By additing back the Leu-2a+ T lymphocytes into autologous T lymphocyte subpopulations, the specific response to the adult worm antigen was completely suppressed. These findings clearly demonstrate the existence of Leu-2a+3a- suppressor T lymphocytes that can control low responsiveness to the schistosomal adult worm antigen in man.

本文言語英語
ページ(範囲)2524-2528
ページ数5
ジャーナルJournal of Immunology
131
5
出版ステータス出版済み - 12 1 1983
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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「Antigen-specific suppressor T lymphocytes (Leu-2a<sup>+</sup>3a<sup>-</sup>) in human Schistosomiasis japonica」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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