Antioxidant and cytoprotective activities of methanolic extract from Garcinia mangostana hulls

Nuttavut Kosem, Youn Hee Han, Primchanien Moongkarndi

研究成果: Contribution to journalArticle査読

40 被引用数 (Scopus)

抄録

Garcinia mangostana has been documented in Thai traditional medicine in various aspects. Although many benefits have been claimed, few scientific reports are available in the literature. In the present study, the methanolic extract from G. mangostana hulls (GME) was assessed for antioxidant and cytoprotective activities. The results showed that GME contained phenolic compounds and possessed reducing power as well as Fe2+ chelating activity. The antioxidant properties were determined by scavenging DPPH, nitric oxide and lipid radicals in dose-dependent manners. In particular, the powerful scavenging activities were found against hydroxyl and superoxide radicals when investigated using ESR spectrometry. GME also enhanced the cell survival by decreasing the oxidative damage in ECV304 endothelial cells after H 2O2 exposure. These data indicated that GME played a pivotal role on the antioxidant and chemopreventive activities via a reducing mechanism and inhibition of intracellular oxidative stress, respectively.

本文言語英語
ページ(範囲)283-292
ページ数10
ジャーナルScienceAsia
33
3
DOI
出版ステータス出版済み - 9 2007
外部発表はい

All Science Journal Classification (ASJC) codes

  • General

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