抄録
Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species. However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. In addition, AHR signalling accelerates epidermal terminal differentiation, but excessive acceleration by oxidative ligands, such as dioxins, may induce chlo-racne and inflammation. However, antioxidative phytochemical ligands induce the beneficial acceleration of epidermal differentiation that repairs skin barrier disruption. The upregulated expression of differentiation molecules, such as filaggrin, is mediated via the AHR-OVOL1 axis. This AHR-OVOL1 system is capable of counteracting skin barrier dysfunction in T-helper type 2-shifted inflammation. This article reviews the dynamic and multifaceted role of AHR in epidermal biology and discusses the potential use of antioxidative phytochemical ligands for AHR in inflammatory skin diseases, such as atopic dermatitis.
元の言語 | 英語 |
---|---|
ページ(範囲) | 918-923 |
ページ数 | 6 |
ジャーナル | Acta Dermato-Venereologica |
巻 | 98 |
発行部数 | 10 |
DOI | |
出版物ステータス | 出版済み - 10 2018 |
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All Science Journal Classification (ASJC) codes
- Dermatology
これを引用
Antioxidative phytochemicals accelerate epidermal terminal differentiation via the AHR-OVOL1 pathway : Implications for atopic dermatitis. / Furue, Masutaka; Hashimoto-Hachiya, Akiko; Tsuji, Gaku.
:: Acta Dermato-Venereologica, 巻 98, 番号 10, 10.2018, p. 918-923.研究成果: ジャーナルへの寄稿 › 評論記事
}
TY - JOUR
T1 - Antioxidative phytochemicals accelerate epidermal terminal differentiation via the AHR-OVOL1 pathway
T2 - Implications for atopic dermatitis
AU - Furue, Masutaka
AU - Hashimoto-Hachiya, Akiko
AU - Tsuji, Gaku
PY - 2018/10
Y1 - 2018/10
N2 - Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species. However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. In addition, AHR signalling accelerates epidermal terminal differentiation, but excessive acceleration by oxidative ligands, such as dioxins, may induce chlo-racne and inflammation. However, antioxidative phytochemical ligands induce the beneficial acceleration of epidermal differentiation that repairs skin barrier disruption. The upregulated expression of differentiation molecules, such as filaggrin, is mediated via the AHR-OVOL1 axis. This AHR-OVOL1 system is capable of counteracting skin barrier dysfunction in T-helper type 2-shifted inflammation. This article reviews the dynamic and multifaceted role of AHR in epidermal biology and discusses the potential use of antioxidative phytochemical ligands for AHR in inflammatory skin diseases, such as atopic dermatitis.
AB - Aryl hydrocarbon receptor (AHR) is a chemical sensor that is expressed abundantly in epidermal keratinocytes. Oxidative AHR ligands induce the production of reactive oxygen species. However, antioxidant AHR ligands inhibit reactive oxygen species generation via activation of nuclear factor-erythroid 2-related factor-2, which is a master switch for antioxidative signalling. In addition, AHR signalling accelerates epidermal terminal differentiation, but excessive acceleration by oxidative ligands, such as dioxins, may induce chlo-racne and inflammation. However, antioxidative phytochemical ligands induce the beneficial acceleration of epidermal differentiation that repairs skin barrier disruption. The upregulated expression of differentiation molecules, such as filaggrin, is mediated via the AHR-OVOL1 axis. This AHR-OVOL1 system is capable of counteracting skin barrier dysfunction in T-helper type 2-shifted inflammation. This article reviews the dynamic and multifaceted role of AHR in epidermal biology and discusses the potential use of antioxidative phytochemical ligands for AHR in inflammatory skin diseases, such as atopic dermatitis.
UR - http://www.scopus.com/inward/record.url?scp=85056286879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85056286879&partnerID=8YFLogxK
U2 - 10.2340/00015555-3003
DO - 10.2340/00015555-3003
M3 - Review article
C2 - 29972223
AN - SCOPUS:85056286879
VL - 98
SP - 918
EP - 923
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 10
ER -