Antithrombin III stimulates prostacyclin production by cultured aortic endothelial cells

Teruaki Yamauchi, Fumio Umeda, Toyoshi Inoguchi, Hajime Nawata

    研究成果: Contribution to journalArticle査読

    129 被引用数 (Scopus)

    抄録

    Prostacyclin (PGI2) is a potent vasodilator and an inhibitor of platelet aggregation. We found that antithrombin III (AT III), an anticoagulant present in circulating blood, stimulated PGI2 production by cultured bovine aortic endothelial cells in a dose- and time-dependent manner. The stimulation of PGI2 production by AT III was observed at physiological concentrations and was inhibited by the addition of anti-AT III antiserum and heparin. These results suggest that AT III may stimulate PGI2 production by binding to heparin-like molecules on the endothelial cell membrane.

    本文言語英語
    ページ(範囲)1404-1411
    ページ数8
    ジャーナルBiochemical and Biophysical Research Communications
    163
    3
    DOI
    出版ステータス出版済み - 9 29 1989

    All Science Journal Classification (ASJC) codes

    • 生物理学
    • 生化学
    • 分子生物学
    • 細胞生物学

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