Antitrypanosomal activities and mechanisms of action of novel tetracyclic iridoids from Morinda lucida Benth

Kofi D. Kwofie, Nguyen Huu Tung, Mitsuko Suzuki-Ohashi, Michael Amoa-Bosompem, Richard Adegle, Maxwell M. Sakyiamah, Frederick Ayertey, Kofi Baffour Awuah Owusu, Isaac Tuffour, Philip Atchoglo, Kwadwo K. Frempong, William K. Anyan, Takuhiro Uto, Osamu Morinaga, Taizo Yamashita, Frederic Aboagye, Alfred A. Appiah, Regina Appiah-Opong, Alexander K. Nyarko, Yasuchika YamaguchiDominic Edoh, Kwadwo A. Koram, Shoji Yamaoka, Daniel A. Boakye, Nobuo Ohta, Yukihiro Shoyama, Irene Ayi

研究成果: Contribution to journalArticle査読

18 被引用数 (Scopus)

抄録

Trypanosoma brucei parasites are kinetoplastid protozoa that devastate the health and economic well-being of millions of people in Africa through the disease human African trypanosomiasis (HAT). New chemotherapy has been eagerly awaited due to severe side effects and the drug resistance issues plaguing current drugs. Recently, there has been an emphasis on the use of medicinal plants worldwide. Morinda lucida Benth. is a popular medicinal plant widely distributed in Africa, and several research groups have reported on the antiprotozoal activities of this plant. In this study, we identified three novel tetracyclic iridoids, molucidin, ML-2-3, and ML-F52, from the CHCl3 fraction of M. lucida leaves, which possess activity against the GUTat 3.1 strain of T. brucei brucei. The 50% inhibitory concentrations (IC50) of molucidin, ML-2-3, and ML-F52 were 1.27 μM, 3.75 μM, and 0.43 μM, respectively. ML-2-3 and ML-F52 suppressed the expression of paraflagellum rod protein subunit 2, PFR-2, and caused cell cycle alteration, which preceded apoptosis induction in the bloodstream form of Trypanosoma parasites. Novel tetracyclic iridoids may be promising lead compounds for the development of new chemotherapies for African trypanosomal infections in humans and animals.

本文言語英語
ページ(範囲)3283-3290
ページ数8
ジャーナルAntimicrobial Agents and Chemotherapy
60
6
DOI
出版ステータス出版済み - 6 2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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