Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea

Shigeru Yoshizawa, Takahiko Horiuchi, Hirota Fujiki, Takashi Yoshida, Takuo Okuda, Takashi Sugimura

研究成果: Contribution to journalArticle査読

273 被引用数 (Scopus)

抄録

(−)‐Epigallocatechin gallate (EGCG) is the main polyphenolic constituent of extracts of green tea. EGCG slightly inhibited specific binding of [3H] 12‐0‐tetradecanoylphorbol‐13‐acetate ([3H]TPA) to a particulate fraction of mouse skin, and caused a prompt decrease in the phorbol ester receptor number in mouse skin. It also inhibited the activation of protein kinase C by teleocidin. In week 25 of a two‐stage carcinogenesis experiment in mouse skin, tumors were found in 53% of the mice treated with 7,12‐dimethylbenz(a)anthracene (DMBA) plus teleocidin, but in only 13% of those treated with DMBA plus teleocidin and EGCG. The average number of tumors per mouse in these groups was 2.1 and 0.1, respectively. No tumors were found in other groups treated with DMBA alone or teleocidin and EGCG alone. Thus EGCG inhibited tumor promotion by teleocidin.

本文言語英語
ページ(範囲)44-47
ページ数4
ジャーナルPhytotherapy Research
1
1
DOI
出版ステータス出版済み - 3 1987
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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