Antiviral functions of CD8+ cytotoxic T cells in teleost fish

Tomonori Somamoto, Erling Olaf Koppang, Uwe Fischer

研究成果: Contribution to journalReview article査読

33 被引用数 (Scopus)

抄録

Cytotoxic T-cells (CTLs) play a pivotal role in eliminating viruses in mammalian adaptive immune system. Many recent studies on T-cell immunity of fish have suggested that teleost CTLs are also important for antiviral immunity. Cellular functional studies using clonal ginbuan crucian carp and rainbow trout have provided in vivo and in vitro evidence that in many respects, virus-specific CTLs of fish have functions similar to those of mammalian CTLs. In addition, mRNA expression profiles of CTL-related molecules, such as CD8, TCR and MHC class I, have shown that in a wide range of fish species, CTLs are involved in antiviral adaptive immunity. These findings are a basis to formulate possible vaccination strategies to trigger effective antiviral CTL responses in teleost fish. This review describes recent advances in our understanding of antiviral CTL functions in teleost fish and discusses vaccination strategies for efficiently inducing CTL activities.

本文言語英語
ページ(範囲)197-204
ページ数8
ジャーナルDevelopmental and Comparative Immunology
43
2
DOI
出版ステータス出版済み - 4 2014

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 発生生物学

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