Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome

Jun Usami, Kenji Hiromatsu, Yoshiyasu Aoki, Noritada Kobayashi, Masahiko Makino, Hideo Yagita, Yoshihiro Matsumoto, Kenji Maeda, Yasunobu Yoshikai

    研究成果: Contribution to journalArticle査読

    8 被引用数 (Scopus)

    抄録

    CD95 (Fas)/CD95 ligand (CD95 L)-mediated apoptosis is thought to be involved in the delayed progression of murine AIDS (MAIDS) induced by LP-BM5 murine leukemia virus (MuLV). We show evidence of apoptosis in lymphocytes of Peyer's patches (PP) at the early stage of MAIDS. Both T and B cells in PP expressed CD95 at the early stage of MAIDS and decreased in number thereafter. The decrease in T cells was not evident in CD95-mutated lpr mice with MAIDS, suggesting that CD95/CD95 L interaction is involved in the apoptosis of T cells in PP during the course of MAIDS. On the other hand, the number of B cells was also decreased in PP of lpr mice with MAIDS. The proliferative ability of B cells in PP of MAIDS mice in response to immunoglobulin M cross-linking or lipopolysaccharide was severely impaired, while the B cells normally proliferated in response to anti-CD40 monoclonal antibody. These findings imply that aberrantly activated B cells in PP undergo apoptosis independently of the CD95/CD95 L system during the course of infection with MAIDS virus.

    本文言語英語
    ページ(範囲)8917-8925
    ページ数9
    ジャーナルJournal of virology
    70
    12
    DOI
    出版ステータス出版済み - 12 1996

    All Science Journal Classification (ASJC) codes

    • 微生物学
    • 免疫学
    • 昆虫科学
    • ウイルス学

    フィンガープリント

    「Apoptosis by CD95 (Fas)-dependent and -independent mechanisms in Peyer's patch lymphocytes in murine retrovirus-induced immunodeficiency syndrome」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル