Apoptosis in perforated cornea of a patient with graft-versus-host disease

Ayako Yoshida, Yoh Ichi Kawano, Kouji Kato, Shigeo Yoshida, Hiroshi Yoshikawa, Tsuyoshi Muta, Tetsuya Eto, Hisashi Gondo, Tsunefumi Shibuya, Tatsuro Ishibashi, Toshiko Yamana

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)


Case report: Although ocular complications associated with graft-versus-host disease (GVHD) can include corneal dysfunction, corneal perforation is not common. We report the presence of apoptotic cells in a perforated cornea of a patient with GVHD. A 72-year-old man with the angioimmunoblastic type of malignant lymphoma developed chronic GVHD after allogeneic peripheral blood stem cell transplantation. Despite systemic and topical treatment, both corneas perforated, and penetrating keratoplasty with cataract extraction and intraocular lens implantation was performed on both eyes. Comments: The corneal button excised from the right eye was examined histologically and stained for apoptotic cells by TdT-mediated dUTP nick end labeling (TUNEL). This revealed thinning of the epithelial cell layer and stroma, with cells, including lymphocytes, infiltrating to the site of the perforation. Some of the epithelial cells and keratocytes were TUNEL positive. The presence of apoptotic cells in our case suggests that apoptosis may be involved in the perforation of the cornea in patients with GVHD.

ジャーナルCanadian Journal of Ophthalmology
出版ステータス出版済み - 8 2006

All Science Journal Classification (ASJC) codes

  • 眼科学


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