Apoptosis signaling pathways in lung diseases.

K. Kuwano, M. Yoshimi, T. Maeyama, N. Hamada, M. Yamada, Y. Nakanishi

研究成果: Contribution to journalReview article査読

23 被引用数 (Scopus)

抄録

Evidence that apoptosis plays an important role in the pathophysiology of lung diseases has been accumulated. Apoptosis signaling is classically composed of two principle pathways. One is a direct pathway from death receptor ligation to caspase cascade activation and cell death. Death receptor ligation triggers recruitment of the precursor form of caspase-8 to a death-inducing complex, through the adaptor protein FADD, which leads to caspase-8 activation. The other pathway triggered by stimuli such as drugs, radiation, infectious agents and reactive oxygen species is initiated in mitochondria. After cytochrome c is released into the cytosol from the mitochondria, it binds to Apaf1 and ATP, which then activate caspase-9. Recently, endoplasmic reticulum has also been shown to be the organelle to execute apoptosis. Further understanding of molecular mechanisms of apoptosis and its regulation by novel drugs may lead to the development of effective strategies against lung diseases. We overview the signaling pathways of apoptosis and discuss the involvement of apoptosis in the pathophysiology of various lung diseases.

本文言語英語
ページ(範囲)49-56
ページ数8
ジャーナルMedicinal chemistry
1
1
DOI
出版ステータス出版済み - 1 2005

All Science Journal Classification (ASJC) codes

  • 創薬

フィンガープリント

「Apoptosis signaling pathways in lung diseases.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル