Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy

Masamitsu Hatakenaka, Katsumasa Nakamura, Hidetake Yabuuchi, Yoshiyuki Shioyama, Yoshio Matsuo, Takeshi Kamitani, Masato Yonezawa, Takashi Yoshiura, Torahiko Nakashima, Mitsuru Mori, Hiroshi Honda

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

Purpose: To evaluate the correlation between apparent diffusion coefficient (ADC) and prognosis in head and neck squamous cell carcinoma (HNSCC) treated with radiotherapy. Materials and methods: We retrospectively studied 41 patients (38 male and 3 female, ages 37-85 years) diagnosed with HNSCC (14 oropharynx, 22 hypopharynx, 4 larynx, 1 oral cavity) and treated with radiotherapy, with radiation dose to gross tumor volume over 60 Gy. The association between age, gender, performance status, tumor location, T stage, N stage, stage, dose, overall treatment time, treatment method, adjuvant therapy, or ADC and prognosis was analyzed using a Cox proportional hazard test. Results: ADC calculated with b-values of 300, 500, 750, and 1,000 s/mm2 (ADC 300-1,000) alone showed a significant correlation with all of the analyses (p = 0.022 for local control, p = 0.0109 for regional control, p = 0.0041 for disease-free survival, and p = 0.0014 for overall survival). ADC calculated with b-values of 0, 100, and 200 s/mm2 (ADC 0-200) showed a significant correlation with overall survival (p = 0.0012). N stage showed a significant correlation with regional control (p = 0.0241). Performance status showed significant association with local control (p = 0.0459), disease-free survival (p = 0.023), and overall survival (p = 0.0151), respectively. Conclusion: ADC is an independent predictor of prognosis in HNSCC treated with radiotherapy.

本文言語英語
ページ(範囲)80-89
ページ数10
ジャーナルJapanese Journal of Radiology
32
2
DOI
出版ステータス出版済み - 2 2014

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

フィンガープリント 「Apparent diffusion coefficient is a prognostic factor of head and neck squamous cell carcinoma treated with radiotherapy」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル