Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients

Ten-Year Outcomes of the Q-Cohort Study

Shigeru Tanaka, Toshiharu Ninomiya, Hiroto Hiyamuta, Masatomo Taniguchi, Masanori Tokumoto, Kosuke Masutani, Hiroaki Ooboshi, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono

研究成果: ジャーナルへの寄稿記事

抄録

There has been limited data discussing the relationship between apparent treatment-resistant hypertension (ATRH) and cardiovascular disease risk in patients receiving maintenance hemodialysis. We analyzed data for 2999 hypertensive patients on maintenance hemodialysis. ATRH was defined as uncontrolled blood pressure despite the use of three or more classes of antihypertensive medications, or four or more classes of antihypertensive medications regardless of blood pressure level. We examined the relationships between ATRH and cardiovascular events using a Cox proportional hazards model. The proportion of participants with ATRH was 18.0% (539/2999). During follow-up (median: 106.6 months, interquartile range: 51.3–121.8 months), 931 patients experienced cardiovascular events including coronary heart disease (n = 424), hemorrhagic stroke (n = 158), ischemic stroke (n = 344), and peripheral arterial disease (n = 242). Compared with the non-ATRH group, the ATRH group showed a significant increased risk of developing cardiovascular disease (hazard ratio [HR]: 1.27; 95% confidence interval [CI]: 1.08–1.49), coronary heart disease (HR: 1.28; 95% CI: 1.01–1.62), ischemic stroke (HR: 1.31; 95% CI: 1.01–1.69), and peripheral arterial disease (HR: 1.42; 95% CI: 1.06–1.91) even after adjusting for potential confounders. This study demonstrated that ATRH was significantly associated with increased cardiovascular risk in hemodialysis patients.

元の言語英語
記事番号1043
ジャーナルScientific reports
9
発行部数1
DOI
出版物ステータス出版済み - 12 1 2019

Fingerprint

Renal Dialysis
Cohort Studies
Hypertension
Confidence Intervals
Peripheral Arterial Disease
Stroke
Antihypertensive Agents
Therapeutics
Coronary Disease
Cardiovascular Diseases
Maintenance
Blood Pressure
Proportional Hazards Models

All Science Journal Classification (ASJC) codes

  • General

これを引用

Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients : Ten-Year Outcomes of the Q-Cohort Study. / Tanaka, Shigeru; Ninomiya, Toshiharu; Hiyamuta, Hiroto; Taniguchi, Masatomo; Tokumoto, Masanori; Masutani, Kosuke; Ooboshi, Hiroaki; Nakano, Toshiaki; Tsuruya, Kazuhiko; Kitazono, Takanari.

:: Scientific reports, 巻 9, 番号 1, 1043, 01.12.2019.

研究成果: ジャーナルへの寄稿記事

Tanaka, Shigeru ; Ninomiya, Toshiharu ; Hiyamuta, Hiroto ; Taniguchi, Masatomo ; Tokumoto, Masanori ; Masutani, Kosuke ; Ooboshi, Hiroaki ; Nakano, Toshiaki ; Tsuruya, Kazuhiko ; Kitazono, Takanari. / Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients : Ten-Year Outcomes of the Q-Cohort Study. :: Scientific reports. 2019 ; 巻 9, 番号 1.
@article{9858051c7927457194461f64266f2af6,
title = "Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients: Ten-Year Outcomes of the Q-Cohort Study",
abstract = "There has been limited data discussing the relationship between apparent treatment-resistant hypertension (ATRH) and cardiovascular disease risk in patients receiving maintenance hemodialysis. We analyzed data for 2999 hypertensive patients on maintenance hemodialysis. ATRH was defined as uncontrolled blood pressure despite the use of three or more classes of antihypertensive medications, or four or more classes of antihypertensive medications regardless of blood pressure level. We examined the relationships between ATRH and cardiovascular events using a Cox proportional hazards model. The proportion of participants with ATRH was 18.0{\%} (539/2999). During follow-up (median: 106.6 months, interquartile range: 51.3–121.8 months), 931 patients experienced cardiovascular events including coronary heart disease (n = 424), hemorrhagic stroke (n = 158), ischemic stroke (n = 344), and peripheral arterial disease (n = 242). Compared with the non-ATRH group, the ATRH group showed a significant increased risk of developing cardiovascular disease (hazard ratio [HR]: 1.27; 95{\%} confidence interval [CI]: 1.08–1.49), coronary heart disease (HR: 1.28; 95{\%} CI: 1.01–1.62), ischemic stroke (HR: 1.31; 95{\%} CI: 1.01–1.69), and peripheral arterial disease (HR: 1.42; 95{\%} CI: 1.06–1.91) even after adjusting for potential confounders. This study demonstrated that ATRH was significantly associated with increased cardiovascular risk in hemodialysis patients.",
author = "Shigeru Tanaka and Toshiharu Ninomiya and Hiroto Hiyamuta and Masatomo Taniguchi and Masanori Tokumoto and Kosuke Masutani and Hiroaki Ooboshi and Toshiaki Nakano and Kazuhiko Tsuruya and Takanari Kitazono",
year = "2019",
month = "12",
day = "1",
doi = "10.1038/s41598-018-37961-1",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Apparent Treatment-Resistant Hypertension and Cardiovascular Risk in Hemodialysis Patients

T2 - Ten-Year Outcomes of the Q-Cohort Study

AU - Tanaka, Shigeru

AU - Ninomiya, Toshiharu

AU - Hiyamuta, Hiroto

AU - Taniguchi, Masatomo

AU - Tokumoto, Masanori

AU - Masutani, Kosuke

AU - Ooboshi, Hiroaki

AU - Nakano, Toshiaki

AU - Tsuruya, Kazuhiko

AU - Kitazono, Takanari

PY - 2019/12/1

Y1 - 2019/12/1

N2 - There has been limited data discussing the relationship between apparent treatment-resistant hypertension (ATRH) and cardiovascular disease risk in patients receiving maintenance hemodialysis. We analyzed data for 2999 hypertensive patients on maintenance hemodialysis. ATRH was defined as uncontrolled blood pressure despite the use of three or more classes of antihypertensive medications, or four or more classes of antihypertensive medications regardless of blood pressure level. We examined the relationships between ATRH and cardiovascular events using a Cox proportional hazards model. The proportion of participants with ATRH was 18.0% (539/2999). During follow-up (median: 106.6 months, interquartile range: 51.3–121.8 months), 931 patients experienced cardiovascular events including coronary heart disease (n = 424), hemorrhagic stroke (n = 158), ischemic stroke (n = 344), and peripheral arterial disease (n = 242). Compared with the non-ATRH group, the ATRH group showed a significant increased risk of developing cardiovascular disease (hazard ratio [HR]: 1.27; 95% confidence interval [CI]: 1.08–1.49), coronary heart disease (HR: 1.28; 95% CI: 1.01–1.62), ischemic stroke (HR: 1.31; 95% CI: 1.01–1.69), and peripheral arterial disease (HR: 1.42; 95% CI: 1.06–1.91) even after adjusting for potential confounders. This study demonstrated that ATRH was significantly associated with increased cardiovascular risk in hemodialysis patients.

AB - There has been limited data discussing the relationship between apparent treatment-resistant hypertension (ATRH) and cardiovascular disease risk in patients receiving maintenance hemodialysis. We analyzed data for 2999 hypertensive patients on maintenance hemodialysis. ATRH was defined as uncontrolled blood pressure despite the use of three or more classes of antihypertensive medications, or four or more classes of antihypertensive medications regardless of blood pressure level. We examined the relationships between ATRH and cardiovascular events using a Cox proportional hazards model. The proportion of participants with ATRH was 18.0% (539/2999). During follow-up (median: 106.6 months, interquartile range: 51.3–121.8 months), 931 patients experienced cardiovascular events including coronary heart disease (n = 424), hemorrhagic stroke (n = 158), ischemic stroke (n = 344), and peripheral arterial disease (n = 242). Compared with the non-ATRH group, the ATRH group showed a significant increased risk of developing cardiovascular disease (hazard ratio [HR]: 1.27; 95% confidence interval [CI]: 1.08–1.49), coronary heart disease (HR: 1.28; 95% CI: 1.01–1.62), ischemic stroke (HR: 1.31; 95% CI: 1.01–1.69), and peripheral arterial disease (HR: 1.42; 95% CI: 1.06–1.91) even after adjusting for potential confounders. This study demonstrated that ATRH was significantly associated with increased cardiovascular risk in hemodialysis patients.

UR - http://www.scopus.com/inward/record.url?scp=85060943347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060943347&partnerID=8YFLogxK

U2 - 10.1038/s41598-018-37961-1

DO - 10.1038/s41598-018-37961-1

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 1043

ER -