Application of bioinformatics for DNA microarray data to bioscience, bioengineering and medical fields

Taizo Hanai, Hiroyuki Hamada, Masahiro Okamoto

研究成果: ジャーナルへの寄稿学術誌査読

27 被引用数 (Scopus)

抄録

In the 1990s, DNA microarray or DNA chip as a novel biological experimental technology was developed, which enables the comprehensive measurement of the expression levels of hundreds of genes, simultaneously. Using this technique, a comprehensive understanding of the cell can be achieved. However, because even simple life forms, such as microorganisms, have more than a thousand kinds of genes, the data from a DNA chip cannot be analyzed without statistical and informational technology. Bioinformatics is the interdisciplinary research field integrating molecular biology with informatics, and it is expected to have a huge impact on the bioscientific, bioengineering and medical fields. There are many techniques in bioinformatics for the analysis of DNA microarray data; however, these are mainly divided into fold-change analysis, clustering, classification, genetic network analysis, and simulation. In this review, these techniques are briefly explained by using some examples.

本文言語英語
ページ(範囲)377-384
ページ数8
ジャーナルJournal of Bioscience and Bioengineering
101
5
DOI
出版ステータス出版済み - 5月 2006

!!!All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • バイオエンジニアリング
  • 応用微生物学とバイオテクノロジー

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