Application of recombinant thioredoxin1 for treatment of heart disease

Shouji Matsushima, Daniela Zablocki, Junichi Sadoshima

研究成果: Contribution to journalReview article査読

20 被引用数 (Scopus)

抄録

Thioredoxin 1 (Trx1) is a small molecule with reactive cysteines that reduces proteins with disulfide bonds through a thiol disulfide exchange reaction. Accumulating lines of evidence suggest that Trx1 protects the heart from ischemia/reperfusion injury, pathological hypertrophy, and inflammation; induces preconditioning effects and angiogenesis; and upregulates mitochondrial genes. Exogenously given recombinant Trx1 (r-Trx1) may protect the heart through its actions in both extracellular and intracellular spaces. In this brief review, the potential of Trx1 therapy for heart disease is discussed. This article is part of a special issue entitled "Key Signaling Molecules in Hypertrophy and Heart Failure.".

本文言語英語
ページ(範囲)570-573
ページ数4
ジャーナルJournal of Molecular and Cellular Cardiology
51
4
DOI
出版ステータス出版済み - 10 2011

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

フィンガープリント 「Application of recombinant thioredoxin1 for treatment of heart disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル