Application of schizophyllan as a novel gene carrier.

K. Sakurai, T. Kimura, K. Koumoto, M. Mizu, R. Kobayashi, S. Shinkai

研究成果: Contribution to journalArticle

8 引用 (Scopus)

抜粋

Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.

元の言語英語
ページ(範囲)223-224
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
発行部数1
DOI
出版物ステータス出版済み - 2001
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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  • これを引用

    Sakurai, K., Kimura, T., Koumoto, K., Mizu, M., Kobayashi, R., & Shinkai, S. (2001). Application of schizophyllan as a novel gene carrier. Nucleic acids research. Supplement (2001), (1), 223-224. https://doi.org/10.1093/nass/1.1.223