Application of schizophyllan as a novel gene carrier.

K. Sakurai, T. Kimura, K. Koumoto, M. Mizu, R. Kobayashi, S. Shinkai

研究成果: Contribution to journalArticle査読

8 被引用数 (Scopus)

抄録

Schizophyllan (SPG) is a kind of beta-1,3-glucan which has glucose side chain through a beta-1,6-glycosil bond (Fig. 1). It was found that SPG could form complex with single stranded polynucleotides. SPG forms triple stranded complex with single stranded RNAs thorough hydrogen bonding and hydrophobic interaction. It was found tht polynucleotide was protected from nuclease attacking to form the complex with SPG, and SPG enhanced antisense efficient.

本文言語英語
ページ(範囲)223-224
ページ数2
ジャーナルNucleic acids research. Supplement (2001)
1
DOI
出版ステータス出版済み - 2001
外部発表はい

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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