Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese

Takuya Matsushita, Noriko Isobe, T. Matsuoka, N. Shi, Y. Kawano, X. M. Wu, T. Yoshiura, Y. Nakao, T. Ishizu, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

63 引用 (Scopus)

抄録

Background: Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease. Objective: The objective of the current study was to clarify immunological differences between the two groups of patients. Methods: We studied the serum antibody titers against AQP4 in 191 patients with idiopathic central nervous system demyelinating diseases and clarified their relationships with immunological parameters. Results: Anti-AQP4 antibody positivity rate was higher in patients with OSMS (21/58, 36.2%), idiopathic recurrent myelitis (4/17, 23.5%), and recurrent optic neuritis (7/26, 26.9%), than in conventional MS (CMS) patients (6/90, 6.7%) and patients with other diseases (0/87). Anti-AQP4 antibody titer was significantly higher in patients with SS-A/B antibodies than in those without them. Anti-AQP4 antibody-negative OSMS patients showed significantly higher CD4+ IFN-γ+IL-4γT cell percentages and intracellular IFN-γ/IL-4 ratios than anti-AQP4 antibody-positive patients, anti-AQP4 antibody-negative CMS patients, and healthy controls, and CD4+IFN-γ+IL-4-T cell percentages were negatively correlated with anti-AQP4 antibody titers. Conclusion: Anti-AQP4 antibody-positive patients are immunologically distinct from anti-AQP4 antibody-negative OSMS patients owing to a Th2 shift in the former group in comparison to a Th1 shift in the latter.

元の言語英語
ページ(範囲)834-847
ページ数14
ジャーナルMultiple Sclerosis
15
発行部数7
DOI
出版物ステータス出版済み - 7 1 2009

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Aquaporin 4
Antibodies
Interleukin-4
Opticospinal Multiple Sclerosis
Myelitis
Optic Neuritis
Central Nervous System Diseases
Demyelinating Diseases

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. / Matsushita, Takuya; Isobe, Noriko; Matsuoka, T.; Shi, N.; Kawano, Y.; Wu, X. M.; Yoshiura, T.; Nakao, Y.; Ishizu, T.; Kira, Jun-Ichi.

:: Multiple Sclerosis, 巻 15, 番号 7, 01.07.2009, p. 834-847.

研究成果: ジャーナルへの寄稿記事

Matsushita, Takuya ; Isobe, Noriko ; Matsuoka, T. ; Shi, N. ; Kawano, Y. ; Wu, X. M. ; Yoshiura, T. ; Nakao, Y. ; Ishizu, T. ; Kira, Jun-Ichi. / Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese. :: Multiple Sclerosis. 2009 ; 巻 15, 番号 7. pp. 834-847.
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title = "Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese",
abstract = "Background: Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease. Objective: The objective of the current study was to clarify immunological differences between the two groups of patients. Methods: We studied the serum antibody titers against AQP4 in 191 patients with idiopathic central nervous system demyelinating diseases and clarified their relationships with immunological parameters. Results: Anti-AQP4 antibody positivity rate was higher in patients with OSMS (21/58, 36.2{\%}), idiopathic recurrent myelitis (4/17, 23.5{\%}), and recurrent optic neuritis (7/26, 26.9{\%}), than in conventional MS (CMS) patients (6/90, 6.7{\%}) and patients with other diseases (0/87). Anti-AQP4 antibody titer was significantly higher in patients with SS-A/B antibodies than in those without them. Anti-AQP4 antibody-negative OSMS patients showed significantly higher CD4+ IFN-γ+IL-4γT cell percentages and intracellular IFN-γ/IL-4 ratios than anti-AQP4 antibody-positive patients, anti-AQP4 antibody-negative CMS patients, and healthy controls, and CD4+IFN-γ+IL-4-T cell percentages were negatively correlated with anti-AQP4 antibody titers. Conclusion: Anti-AQP4 antibody-positive patients are immunologically distinct from anti-AQP4 antibody-negative OSMS patients owing to a Th2 shift in the former group in comparison to a Th1 shift in the latter.",
author = "Takuya Matsushita and Noriko Isobe and T. Matsuoka and N. Shi and Y. Kawano and Wu, {X. M.} and T. Yoshiura and Y. Nakao and T. Ishizu and Jun-Ichi Kira",
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T1 - Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese

AU - Matsushita, Takuya

AU - Isobe, Noriko

AU - Matsuoka, T.

AU - Shi, N.

AU - Kawano, Y.

AU - Wu, X. M.

AU - Yoshiura, T.

AU - Nakao, Y.

AU - Ishizu, T.

AU - Kira, Jun-Ichi

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background: Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease. Objective: The objective of the current study was to clarify immunological differences between the two groups of patients. Methods: We studied the serum antibody titers against AQP4 in 191 patients with idiopathic central nervous system demyelinating diseases and clarified their relationships with immunological parameters. Results: Anti-AQP4 antibody positivity rate was higher in patients with OSMS (21/58, 36.2%), idiopathic recurrent myelitis (4/17, 23.5%), and recurrent optic neuritis (7/26, 26.9%), than in conventional MS (CMS) patients (6/90, 6.7%) and patients with other diseases (0/87). Anti-AQP4 antibody titer was significantly higher in patients with SS-A/B antibodies than in those without them. Anti-AQP4 antibody-negative OSMS patients showed significantly higher CD4+ IFN-γ+IL-4γT cell percentages and intracellular IFN-γ/IL-4 ratios than anti-AQP4 antibody-positive patients, anti-AQP4 antibody-negative CMS patients, and healthy controls, and CD4+IFN-γ+IL-4-T cell percentages were negatively correlated with anti-AQP4 antibody titers. Conclusion: Anti-AQP4 antibody-positive patients are immunologically distinct from anti-AQP4 antibody-negative OSMS patients owing to a Th2 shift in the former group in comparison to a Th1 shift in the latter.

AB - Background: Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease. Objective: The objective of the current study was to clarify immunological differences between the two groups of patients. Methods: We studied the serum antibody titers against AQP4 in 191 patients with idiopathic central nervous system demyelinating diseases and clarified their relationships with immunological parameters. Results: Anti-AQP4 antibody positivity rate was higher in patients with OSMS (21/58, 36.2%), idiopathic recurrent myelitis (4/17, 23.5%), and recurrent optic neuritis (7/26, 26.9%), than in conventional MS (CMS) patients (6/90, 6.7%) and patients with other diseases (0/87). Anti-AQP4 antibody titer was significantly higher in patients with SS-A/B antibodies than in those without them. Anti-AQP4 antibody-negative OSMS patients showed significantly higher CD4+ IFN-γ+IL-4γT cell percentages and intracellular IFN-γ/IL-4 ratios than anti-AQP4 antibody-positive patients, anti-AQP4 antibody-negative CMS patients, and healthy controls, and CD4+IFN-γ+IL-4-T cell percentages were negatively correlated with anti-AQP4 antibody titers. Conclusion: Anti-AQP4 antibody-positive patients are immunologically distinct from anti-AQP4 antibody-negative OSMS patients owing to a Th2 shift in the former group in comparison to a Th1 shift in the latter.

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U2 - 10.1177/1352458509104595

DO - 10.1177/1352458509104595

M3 - Article

C2 - 19465451

AN - SCOPUS:67649383226

VL - 15

SP - 834

EP - 847

JO - Multiple Sclerosis

JF - Multiple Sclerosis

SN - 1352-4585

IS - 7

ER -