Arachidonic acid supplementation does not affect N-methyl-N-nitrosourea-induced renal Preneoplastic lesions in young Lewis rats

Katsuhiko Yoshizawa, Yuko Emoto, Yuichi Kinoshita, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Tomohito Hamazaki, Airo Tsubura

研究成果: Contribution to journalArticle査読

4 被引用数 (Scopus)

抄録

Arachidonic acid (AA) is naturally found in human breast milk. AA, together with docosahexaenoic acid, is commonly added as a functional food ingredient to commercial infant formula worldwide, in accordance with the international standards of Codex Alimentarius. However, few studies of the possible renal carcinogenic effects of AA supplementation during neonatal life have been performed. The effect of dietary AA supplementation in dams during gestation and lactation was investigated on N-methyl-N-nitrosourea (MNU)-induced preneoplastic lesions in the kidneys of young Lewis rats. Dams were fed a 2.0% AA diet or a basal diet (<0.01% AA). At birth (postnatal day 0), male and female pups received a single intraperitoneal injection of 35 mg/kg MNU or vehicle. Renal morphology was examined after 7, 14, 21, 28 and 60 days. Histopathologically, renal preneoplastic lesions, such as nephroblastomatosis and mesenchymal cell proliferation, were found on day 60 in both the MNU-treated groups. There was no significant difference in lesion incidence of 38% in the basal diet group and 31% in the AA diet group. In conclusion, an AA-rich diet for dams during gestation and lactation does not modify MNU-induced renal preneoplastic lesions in their offspring.

本文言語英語
ページ(範囲)1112-1116
ページ数5
ジャーナルOncology Letters
5
4
DOI
出版ステータス出版済み - 4 2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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