Archaeal ribonuclease P proteins have potential for biotechnological applications where precise hybridization of nucleic acids is needed

Mitsuru Miyanoshita, Takashi Nakashima, Yoshimitsu Kakuta, Makoto Kimura

研究成果: Contribution to journalArticle査読

1 被引用数 (Scopus)

抄録

Fluorescence resonance energy transfer-based assay showed that archaeal ribonuclease P (RNase P) proteins significantly promoted DNA annealing and strand displacement. Moreover, we found that archaeal RNase P proteins could discriminate nucleotide exchanges in DNA chains via their activity accelerating DNA strand displacement, suggesting that they have potential for biotechnological application to genetic diagnosis.

本文言語英語
ページ(範囲)2014-2017
ページ数4
ジャーナルBioscience, Biotechnology and Biochemistry
79
12
DOI
出版ステータス出版済み - 2015

All Science Journal Classification (ASJC) codes

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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