Architecture and shape control of nanoobjects based on amphiphilic dendrimers

Keigo Aoi, Takaaki Fukui, Yoshiharu Otsuka, Keiji Tanaka, Toshihiko Nagamura

研究成果: 会議への寄与タイプ論文

抄録

In the field of nanotechnology and nanoscience, dendrimers are key compounds having well-defined chemical structure. We nave already reported synthesis of globular carbohydrate macro molecule "sugar ball" which is applicable to gene and drug carriers [1-4]. Amphiphilic surface-sugar- substituted surface-block dendrimers have been also designed, synthesized and characterized [4]. Supramolecular architeucture based on amphiphilic dendrimers is important to create shape controlled smart nanoobjects[5]. The present report deals with synthesis and assembly of amphiphilic sugar-substituted poly(ethylene glycol) dendrimers. The dendrimers were synthesized by the reaction of N-acetyl-D-glucosamine, galactose, and lactose derivatives with poly(ethylene glycol) dendrimer having a hydroxy group and alkyl groups at the core and the surface, respectively, wnich were prepared by convergent method. The sugar moieties and the poly(ethylene glycol) dendrimer branches are regarded as hydrophilic parts, whereas the alkyl groups act as hydrophobic groups. Although hydrophobicity of the amphiphilic dendrimers is high, nanoparticles based on the amphiphilic dendrimers can be prepared by irradiation of ultrasonic wave. Fortunately the particle size, which is measured using DLS, could be controlled around ca. 200 nm. Monolayer of the amphiphilic dendrimers was successfully formed at the air/water interface. Intermolecular distance, i.e., intersugar distance, of the monolayer was found to be controlled around 2 nm by changing generation and hydrophobic groups of the dendrimers.

元の言語英語
ページ2715-2716
ページ数2
出版物ステータス出版済み - 12 1 2005
イベント54th SPSJ Symposium on Macromolecules - Yamagata, 日本
継続期間: 9 20 20059 22 2005

その他

その他54th SPSJ Symposium on Macromolecules
日本
Yamagata
期間9/20/059/22/05

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Dendrimers
Sugars
Polyethylene glycols
Monolayers
Glucosamine
Nanoscience
Ultrasonic waves
Carbohydrates
Hydrophobicity
Nanotechnology
Macros
Genes
Particle size
Irradiation
Nanoparticles
Derivatives

All Science Journal Classification (ASJC) codes

  • Engineering(all)

これを引用

Aoi, K., Fukui, T., Otsuka, Y., Tanaka, K., & Nagamura, T. (2005). Architecture and shape control of nanoobjects based on amphiphilic dendrimers. 2715-2716. 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, 日本.

Architecture and shape control of nanoobjects based on amphiphilic dendrimers. / Aoi, Keigo; Fukui, Takaaki; Otsuka, Yoshiharu; Tanaka, Keiji; Nagamura, Toshihiko.

2005. 2715-2716 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, 日本.

研究成果: 会議への寄与タイプ論文

Aoi, K, Fukui, T, Otsuka, Y, Tanaka, K & Nagamura, T 2005, 'Architecture and shape control of nanoobjects based on amphiphilic dendrimers', 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, 日本, 9/20/05 - 9/22/05 pp. 2715-2716.
Aoi K, Fukui T, Otsuka Y, Tanaka K, Nagamura T. Architecture and shape control of nanoobjects based on amphiphilic dendrimers. 2005. 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, 日本.
Aoi, Keigo ; Fukui, Takaaki ; Otsuka, Yoshiharu ; Tanaka, Keiji ; Nagamura, Toshihiko. / Architecture and shape control of nanoobjects based on amphiphilic dendrimers. 論文発表場所 54th SPSJ Symposium on Macromolecules, Yamagata, 日本.2 p.
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