Are free radical reactions increased in the diabetic eye?

Mayumi Yamato, Shingo Matsumoto, Katsuaki Ura, Ken Ichi Yamada, Tatsuya Naganuma, Toyoshi Inoguchi, Toshiaki Watanabe, Hideo Utsumi

研究成果: Contribution to journalReview article

11 引用 (Scopus)


Reactive oxygen species (ROS) are thought to play a significant role in the development of diabetic retinopathy; however, no direct evidence supports ROS generation in vivo. This study used in vivo electron spin resonance (ESR) spectroscopy with a surface resonator to detect local free radical reactions. The ESR signal decay of carbamoyl-PROXYL was enhanced in the eyes of streptozotocin (STZ)-induced diabetic mice. This enhanced signal decay was suppressed by the administration of SOD or the pretreatment with aminoguanidine. We demonstrate, for the first time, specific free radical reactions in the eyes of mice with STZ-induced diabetes.

ジャーナルAntioxidants and Redox Signaling
出版物ステータス出版済み - 3 1 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

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  • これを引用

    Yamato, M., Matsumoto, S., Ura, K., Yamada, K. I., Naganuma, T., Inoguchi, T., Watanabe, T., & Utsumi, H. (2007). Are free radical reactions increased in the diabetic eye? Antioxidants and Redox Signaling, 9(3), 367-373.