Are free radical reactions increased in the diabetic eye?

Mayumi Yamato, Shingo Matsumoto, Katsuaki Ura, Ken Ichi Yamada, Tatsuya Naganuma, Toyoshi Inoguchi, Toshiaki Watanabe, Hideo Utsumi

研究成果: Contribution to journalReview article査読

11 被引用数 (Scopus)

抄録

Reactive oxygen species (ROS) are thought to play a significant role in the development of diabetic retinopathy; however, no direct evidence supports ROS generation in vivo. This study used in vivo electron spin resonance (ESR) spectroscopy with a surface resonator to detect local free radical reactions. The ESR signal decay of carbamoyl-PROXYL was enhanced in the eyes of streptozotocin (STZ)-induced diabetic mice. This enhanced signal decay was suppressed by the administration of SOD or the pretreatment with aminoguanidine. We demonstrate, for the first time, specific free radical reactions in the eyes of mice with STZ-induced diabetes.

本文言語英語
ページ(範囲)367-373
ページ数7
ジャーナルAntioxidants and Redox Signaling
9
3
DOI
出版ステータス出版済み - 3 2007

All Science Journal Classification (ASJC) codes

  • 生化学
  • 生理学
  • 分子生物学
  • 臨床生化学
  • 細胞生物学

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