Arginine metabolism in soft tissue sarcoma

Xiaofeng Yan, Masakazu Takahara, Lining Xie, Chisato Gondo, Nokitaka Setsu, Yoshinao Oda, Satoshi Takeuchi, Yating Tu, Yoichi Moroi, Masutaka Furue

研究成果: ジャーナルへの寄稿レター

4 引用 (Scopus)

抄録

Background: l-Arginine (l-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes. Whether l-Arg metabolism has detrimental or beneficial influence on the tumor growth depends on local up regulation of the NOS or ARG pathways at the tumor site. Objective: To evaluate the expression profile of ARG and iNOS in various histological subtypes of soft tissue sarcomas (STSs). Methods: A series of 81 adult STSs were tested for ARG1, ARG2 and iNOS expression by immunohistochemical analysis. Results: ARG1, ARG2 and iNOS expression was found in tumor cells of all cases of STSs except dermatofibrosarcoma protuberans (DFSP) in a cytoplasmic pattern. However, there was no significant correlation found between ARG, iNOS expression and histopathological parameters. Conversely, the majority of DFSP were devoid of ARG and iNOS expression, while only two cases showed focal and weak expression. Conclusions: Overexpression of l-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs. New knowledge of the regulation of arginine metabolism in tumor tissues is key to designing sound therapeutic means to effectively prevent tumorigenesis. Further studies are needed to clarify the absence of ARG and iNOS staining in DFSP.

元の言語英語
ページ(範囲)211-215
ページ数5
ジャーナルJournal of Dermatological Science
61
発行部数3
DOI
出版物ステータス出版済み - 3 1 2011

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Arginase
Nitric Oxide Synthase Type II
Metabolism
Nitric Oxide Synthase
Sarcoma
Arginine
Dermatofibrosarcoma
Tissue
Tumors
Neoplasms
Cells
Biological Phenomena
Essential Amino Acids
Enzymes
Carcinogenesis
Up-Regulation
Acoustic waves
Staining and Labeling
Substrates
Growth

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

これを引用

Arginine metabolism in soft tissue sarcoma. / Yan, Xiaofeng; Takahara, Masakazu; Xie, Lining; Gondo, Chisato; Setsu, Nokitaka; Oda, Yoshinao; Takeuchi, Satoshi; Tu, Yating; Moroi, Yoichi; Furue, Masutaka.

:: Journal of Dermatological Science, 巻 61, 番号 3, 01.03.2011, p. 211-215.

研究成果: ジャーナルへの寄稿レター

Yan, X, Takahara, M, Xie, L, Gondo, C, Setsu, N, Oda, Y, Takeuchi, S, Tu, Y, Moroi, Y & Furue, M 2011, 'Arginine metabolism in soft tissue sarcoma', Journal of Dermatological Science, 巻. 61, 番号 3, pp. 211-215. https://doi.org/10.1016/j.jdermsci.2010.12.009
Yan, Xiaofeng ; Takahara, Masakazu ; Xie, Lining ; Gondo, Chisato ; Setsu, Nokitaka ; Oda, Yoshinao ; Takeuchi, Satoshi ; Tu, Yating ; Moroi, Yoichi ; Furue, Masutaka. / Arginine metabolism in soft tissue sarcoma. :: Journal of Dermatological Science. 2011 ; 巻 61, 番号 3. pp. 211-215.
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abstract = "Background: l-Arginine (l-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes. Whether l-Arg metabolism has detrimental or beneficial influence on the tumor growth depends on local up regulation of the NOS or ARG pathways at the tumor site. Objective: To evaluate the expression profile of ARG and iNOS in various histological subtypes of soft tissue sarcomas (STSs). Methods: A series of 81 adult STSs were tested for ARG1, ARG2 and iNOS expression by immunohistochemical analysis. Results: ARG1, ARG2 and iNOS expression was found in tumor cells of all cases of STSs except dermatofibrosarcoma protuberans (DFSP) in a cytoplasmic pattern. However, there was no significant correlation found between ARG, iNOS expression and histopathological parameters. Conversely, the majority of DFSP were devoid of ARG and iNOS expression, while only two cases showed focal and weak expression. Conclusions: Overexpression of l-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs. New knowledge of the regulation of arginine metabolism in tumor tissues is key to designing sound therapeutic means to effectively prevent tumorigenesis. Further studies are needed to clarify the absence of ARG and iNOS staining in DFSP.",
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T1 - Arginine metabolism in soft tissue sarcoma

AU - Yan, Xiaofeng

AU - Takahara, Masakazu

AU - Xie, Lining

AU - Gondo, Chisato

AU - Setsu, Nokitaka

AU - Oda, Yoshinao

AU - Takeuchi, Satoshi

AU - Tu, Yating

AU - Moroi, Yoichi

AU - Furue, Masutaka

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N2 - Background: l-Arginine (l-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes. Whether l-Arg metabolism has detrimental or beneficial influence on the tumor growth depends on local up regulation of the NOS or ARG pathways at the tumor site. Objective: To evaluate the expression profile of ARG and iNOS in various histological subtypes of soft tissue sarcomas (STSs). Methods: A series of 81 adult STSs were tested for ARG1, ARG2 and iNOS expression by immunohistochemical analysis. Results: ARG1, ARG2 and iNOS expression was found in tumor cells of all cases of STSs except dermatofibrosarcoma protuberans (DFSP) in a cytoplasmic pattern. However, there was no significant correlation found between ARG, iNOS expression and histopathological parameters. Conversely, the majority of DFSP were devoid of ARG and iNOS expression, while only two cases showed focal and weak expression. Conclusions: Overexpression of l-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs. New knowledge of the regulation of arginine metabolism in tumor tissues is key to designing sound therapeutic means to effectively prevent tumorigenesis. Further studies are needed to clarify the absence of ARG and iNOS staining in DFSP.

AB - Background: l-Arginine (l-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes. Whether l-Arg metabolism has detrimental or beneficial influence on the tumor growth depends on local up regulation of the NOS or ARG pathways at the tumor site. Objective: To evaluate the expression profile of ARG and iNOS in various histological subtypes of soft tissue sarcomas (STSs). Methods: A series of 81 adult STSs were tested for ARG1, ARG2 and iNOS expression by immunohistochemical analysis. Results: ARG1, ARG2 and iNOS expression was found in tumor cells of all cases of STSs except dermatofibrosarcoma protuberans (DFSP) in a cytoplasmic pattern. However, there was no significant correlation found between ARG, iNOS expression and histopathological parameters. Conversely, the majority of DFSP were devoid of ARG and iNOS expression, while only two cases showed focal and weak expression. Conclusions: Overexpression of l-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs. New knowledge of the regulation of arginine metabolism in tumor tissues is key to designing sound therapeutic means to effectively prevent tumorigenesis. Further studies are needed to clarify the absence of ARG and iNOS staining in DFSP.

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