Arginine metabolism in soft tissue sarcoma

Xiaofeng Yan, Masakazu Takahara, Lining Xie, Chisato Gondo, Nokitaka Setsu, Yoshinao Oda, Satoshi Takeuchi, Yating Tu, Yoichi Moroi, Masutaka Furue

研究成果: Contribution to journalLetter査読

5 被引用数 (Scopus)

抄録

Background: l-Arginine (l-Arg) is a conditionally essential amino acid for humans, which is the substrate for both arginase (ARG) and the inducible form of nitric oxide synthase (iNOS) enzymes. Whether l-Arg metabolism has detrimental or beneficial influence on the tumor growth depends on local up regulation of the NOS or ARG pathways at the tumor site. Objective: To evaluate the expression profile of ARG and iNOS in various histological subtypes of soft tissue sarcomas (STSs). Methods: A series of 81 adult STSs were tested for ARG1, ARG2 and iNOS expression by immunohistochemical analysis. Results: ARG1, ARG2 and iNOS expression was found in tumor cells of all cases of STSs except dermatofibrosarcoma protuberans (DFSP) in a cytoplasmic pattern. However, there was no significant correlation found between ARG, iNOS expression and histopathological parameters. Conversely, the majority of DFSP were devoid of ARG and iNOS expression, while only two cases showed focal and weak expression. Conclusions: Overexpression of l-Arg-metabolizing enzymes ARG and iNOS in tumor cells of all of the STS cases except DFSP may have a role in mediating the biological processes which characterize STSs. New knowledge of the regulation of arginine metabolism in tumor tissues is key to designing sound therapeutic means to effectively prevent tumorigenesis. Further studies are needed to clarify the absence of ARG and iNOS staining in DFSP.

本文言語英語
ページ(範囲)211-215
ページ数5
ジャーナルJournal of Dermatological Science
61
3
DOI
出版ステータス出版済み - 3 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 皮膚病学

フィンガープリント

「Arginine metabolism in soft tissue sarcoma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル