Arrhythmogenic and inotropic effects of interferon investigated in perfused and in vivo rat hearts influences of cardiac hypertrophy and isoproterenol

Keita Odashiro, Shin ichi Hiramatsu, Nobuhito Yanagi, Takeshi Arita, Toru Maruyama, Yoshikazu Kaji, Mine Harada

研究成果: ジャーナルへの寄稿学術誌査読

11 被引用数 (Scopus)

抄録

Although the arrhythmogenic effects of interferon (IF) have been reported in clinical practice, the experimental data are limited. Therefore, these effects were investigated in in vivo and Langendorff-perfusion studies using 3 different groups of rats (ie, control, aorta-banded, and deoxycorticosterone acetate (DOCA)-salt hypertension groups) in the presence or absence of isoproterenol. In the perfusion study, human recombinant IF-α (≤15,000 U/ml) alone induced irreversible atrioventricular blockade in all groups, whereas this agent (≤1,500 U/ml) caused negative inotropism and ventricular tachyarrhythmias (arrhythmic score greater in the order of DOCA-salt>aorta-banded = control group) in the preparations pretreated with isoproterenol (10-9 mol/L). In an in vivo study, IF-α (6x106 U/kg) resulted in ventricular tachyarrhythmias only in the presence of isoproterenol (10 mg/kg), as in the perfusion study (arrhythmic score; DOCA-salt>aorta-banded>control). In conclusion, the arrhythmogenesis of IF-α is potentiated in pathophysiological conditions such as cardiac hypertrophy or elevated sympathetic activity.

本文言語英語
ページ(範囲)1161-1167
ページ数7
ジャーナルCirculation Journal
66
12
DOI
出版ステータス出版済み - 12月 1 2002

!!!All Science Journal Classification (ASJC) codes

  • 循環器および心血管医学

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