Artificial induction and disease-related conversion of the hepatic fate

研究成果: ジャーナルへの寄稿評論記事

5 引用 (Scopus)

抄録

Under normal physiological conditions, the fates of cells that compose various parts of organs are determined during development, and never change to those of other cell types. However, recent advances in induction of cellular reprogramming provide chances to generate a completely different cell type from an original cell source by artificially modulating the microenvironments or gene expressions pattern of cells. Although hepatocytes normally only reside in the liver, the hepatic program can be induced in skin-derived fibroblasts by expressing defined extrinsic transcription factors. These induced hepatocyte-like cells have hepatocyte-specific properties and functionally restore damaged hepatic tissues after transplantation. On the other hand, hepatocytes themselves can be converted into biliary lineage cells as a causative factor of hepatic diseases. Thus, blockade of such disease-related reprogramming of the hepatic fate will become a new therapeutic strategy for refractory diseases in the liver. Moreover, hepatocytes could partially accept the pancreatic program by expressing transcription factors required for pancreas development, suggesting that insulin-producing cells could be generated from hepatocytes and used to treat diabetes. The above-mentioned progress will stimulate studies on the molecular nature of cellular identity and plasticity in hepatocytes, and contribute to the development of potential therapies for liver diseases.

元の言語英語
ページ(範囲)579-584
ページ数6
ジャーナルCurrent Opinion in Genetics and Development
23
発行部数5
DOI
出版物ステータス出版済み - 10 1 2013

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Hepatocytes
Liver
Liver Diseases
Transcription Factors
Tissue Transplantation
Liver Transplantation
Pancreas
Fibroblasts
Insulin
Gene Expression
Skin
Therapeutics

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology

これを引用

Artificial induction and disease-related conversion of the hepatic fate. / Suzuki, Atsushi.

:: Current Opinion in Genetics and Development, 巻 23, 番号 5, 01.10.2013, p. 579-584.

研究成果: ジャーナルへの寄稿評論記事

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