Aryl hydrocarbon receptor in atopic dermatitis and psoriasis

Masutaka Furue, Akiko Hashimoto-Hachiya, Gaku Tsuji

研究成果: ジャーナルへの寄稿評論記事

抄録

The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.

元の言語英語
記事番号5424
ジャーナルInternational journal of molecular sciences
20
発行部数21
DOI
出版物ステータス出版済み - 11 1 2019

Fingerprint

dermatitis
Aryl Hydrocarbon Receptors
Atopic Dermatitis
Psoriasis
Aryl Hydrocarbon Receptor Nuclear Translocator
hydrocarbons
Hydrocarbons
Oxidative stress
Oxidative Stress
Skin
Dioxins
Phytochemicals
Xenobiotics
Regulatory T-Lymphocytes
Tryptophan
Transcription factors
Transcription Factors
tryptophan
Ligands
enzymes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

これを引用

Aryl hydrocarbon receptor in atopic dermatitis and psoriasis. / Furue, Masutaka; Hashimoto-Hachiya, Akiko; Tsuji, Gaku.

:: International journal of molecular sciences, 巻 20, 番号 21, 5424, 01.11.2019.

研究成果: ジャーナルへの寄稿評論記事

@article{cdafb33c7ad74c07aa2d9b15d650578b,
title = "Aryl hydrocarbon receptor in atopic dermatitis and psoriasis",
abstract = "The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.",
author = "Masutaka Furue and Akiko Hashimoto-Hachiya and Gaku Tsuji",
year = "2019",
month = "11",
day = "1",
doi = "10.3390/ijms20215424",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "21",

}

TY - JOUR

T1 - Aryl hydrocarbon receptor in atopic dermatitis and psoriasis

AU - Furue, Masutaka

AU - Hashimoto-Hachiya, Akiko

AU - Tsuji, Gaku

PY - 2019/11/1

Y1 - 2019/11/1

N2 - The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.

AB - The aryl hydrocarbon receptor (AHR)/AHR-nuclear translocator (ARNT) system is a sensitive sensor for small molecular, xenobiotic chemicals of exogenous and endogenous origin, including dioxins, phytochemicals, microbial bioproducts, and tryptophan photoproducts. AHR/ARNT are abundantly expressed in the skin. Once activated, the AHR/ARNT axis strengthens skin barrier functions and accelerates epidermal terminal differentiation by upregulating filaggrin expression. In addition, AHR activation induces oxidative stress. However, some AHR ligands simultaneously activate the nuclear factor-erythroid 2-related factor-2 (NRF2) transcription factor, which is a master switch of antioxidative enzymes that neutralizes oxidative stress. The immunoregulatory system governing T-helper 17/22 (Th17/22) and T regulatory cells (Treg) is also regulated by the AHR system. Notably, AHR agonists, such as tapinarof, are currently used as therapeutic agents in psoriasis and atopic dermatitis. In this review, we summarize recent topics on AHR related to atopic dermatitis and psoriasis.

UR - http://www.scopus.com/inward/record.url?scp=85074432886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074432886&partnerID=8YFLogxK

U2 - 10.3390/ijms20215424

DO - 10.3390/ijms20215424

M3 - Review article

C2 - 31683543

AN - SCOPUS:85074432886

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 21

M1 - 5424

ER -