TY - JOUR
T1 - Ascites retention during mogamulizumab treatment in a patient with adult T-cell leukemia/lymphoma
AU - Shima, Takahiro
AU - Kamezaki, Kenjiro
AU - Higashioka, Kazuhiko
AU - Takashima, Shuichiro
AU - Yoshimoto, Goichi
AU - Kato, Koji
AU - Muta, Tsuyoshi
AU - Takenaka, Katsuto
AU - Iwasaki, Hiromi
AU - Miyamoto, Toshihiro
AU - Akashi, Koichi
N1 - Publisher Copyright:
© 2016 The Japanese Society of Internal Medicine.
PY - 2016
Y1 - 2016
N2 - A 74-year-old woman with refractory adult T-cell leukemia/lymphoma (ATLL) received three courses of mogamulizumab. Despite obtaining complete remission, she thereafter presented with progressive ascites. An analysis of the ascites and laboratory tests revealed no evidence of ATLL invasion, infectious disease, or liver cirrhosis. The mogamulizumab concentrations were maintained in the ascites at approximately 10-15% of that in the plasma. Mogamulizumab was considered to be a plausible pathogenesis of her ascites. To the best of our knowledge, this is the first report suggesting mogamulizumab-induced ascites.
AB - A 74-year-old woman with refractory adult T-cell leukemia/lymphoma (ATLL) received three courses of mogamulizumab. Despite obtaining complete remission, she thereafter presented with progressive ascites. An analysis of the ascites and laboratory tests revealed no evidence of ATLL invasion, infectious disease, or liver cirrhosis. The mogamulizumab concentrations were maintained in the ascites at approximately 10-15% of that in the plasma. Mogamulizumab was considered to be a plausible pathogenesis of her ascites. To the best of our knowledge, this is the first report suggesting mogamulizumab-induced ascites.
UR - http://www.scopus.com/inward/record.url?scp=84976570465&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84976570465&partnerID=8YFLogxK
U2 - 10.2169/internalmedicine.55.5987
DO - 10.2169/internalmedicine.55.5987
M3 - Article
C2 - 27374686
AN - SCOPUS:84976570465
SN - 0918-2918
VL - 55
SP - 1793
EP - 1796
JO - Internal Medicine
JF - Internal Medicine
IS - 13
ER -
