Assessment of central visual function in patients with retinitis pigmentosa

Kohta Fujiwara, Yasuhiro Ikeda, Yusuke Murakami, Takashi Tachibana, Jun Funatsu, Yoshito Koyanagi, Shunji Nakatake, Noriko Yoshida, Shintaro Nakao, Toshio Hisatomi, Shigeo Yoshida, Takeshi Yoshitomi, Tatsuro Ishibashi, Koh Hei Sonoda

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

抄録

In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examined 118 patients who were diagnosed with typical RP. Visual acuity (VA), visual field using a Humphrey Field Analyzer with the central 10-2 SITA-Standard program, and optical coherence tomography measurements were obtained. The slopes, which were derived from serial values of mean deviation (MD), macular sensitivity (MS), or foveal sensitivity (FS) obtained for each eye by a linear mixed model, were used for analysis. MS and FS were calculated as the average retinal sensitivity of 12 and 4 central points respectively. There were statistically significant interactions of times with levels of the central subfield thickness (CST) on the slopes of MS and FS. Compared to the eyes without macular complications, the eyes with macular complications had steeper MD, MS and FS slopes, and this interaction was no significant, but marginal trend for the MS or FS slope (P = 0.10, 0.05, respectively). The central retinal sensitivity (i.e., MS and FS) slopes calculated were effective indices of the progression of central visual function in RP.

元の言語英語
記事番号8070
ジャーナルScientific reports
8
発行部数1
DOI
出版物ステータス出版済み - 12 1 2018

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Retinitis Pigmentosa
Optical Coherence Tomography
Visual Fields
Visual Acuity
Longitudinal Studies
Disease Progression
Linear Models

All Science Journal Classification (ASJC) codes

  • General

これを引用

Assessment of central visual function in patients with retinitis pigmentosa. / Fujiwara, Kohta; Ikeda, Yasuhiro; Murakami, Yusuke; Tachibana, Takashi; Funatsu, Jun; Koyanagi, Yoshito; Nakatake, Shunji; Yoshida, Noriko; Nakao, Shintaro; Hisatomi, Toshio; Yoshida, Shigeo; Yoshitomi, Takeshi; Ishibashi, Tatsuro; Sonoda, Koh Hei.

:: Scientific reports, 巻 8, 番号 1, 8070, 01.12.2018.

研究成果: ジャーナルへの寄稿記事

Fujiwara, K, Ikeda, Y, Murakami, Y, Tachibana, T, Funatsu, J, Koyanagi, Y, Nakatake, S, Yoshida, N, Nakao, S, Hisatomi, T, Yoshida, S, Yoshitomi, T, Ishibashi, T & Sonoda, KH 2018, 'Assessment of central visual function in patients with retinitis pigmentosa', Scientific reports, 巻. 8, 番号 1, 8070. https://doi.org/10.1038/s41598-018-26231-9
Fujiwara, Kohta ; Ikeda, Yasuhiro ; Murakami, Yusuke ; Tachibana, Takashi ; Funatsu, Jun ; Koyanagi, Yoshito ; Nakatake, Shunji ; Yoshida, Noriko ; Nakao, Shintaro ; Hisatomi, Toshio ; Yoshida, Shigeo ; Yoshitomi, Takeshi ; Ishibashi, Tatsuro ; Sonoda, Koh Hei. / Assessment of central visual function in patients with retinitis pigmentosa. :: Scientific reports. 2018 ; 巻 8, 番号 1.
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