Assessment of clinical signs associated with adenoviral epidemic keratoconjunctivitis cases in southern Japan between 2011 and 2014

Koki Aoki, Gabriel Gonzalez, Rikutaro Hinokuma, Nobuyo Yawata, Masayuki Tsutsumi, Shigeaki Ohno, Nobuyoshi Kitaichi

研究成果: Contribution to journalArticle査読

2 被引用数 (Scopus)

抄録

Adenoviral epidemic keratoconjunctivitis (EKC) is a major cause of ocular morbidity worldwide and specific antiviral therapies are not available. EKC is primarily caused by Human adenovirus D (HAdV-D) types 8, 37, 53, 54, 56 and 64. Considering the genomic variation in HAdV-D, we hypothesized that clinical signs could be differentiated by virus type. The hypothesis was retrospectively tested with clinical signs recorded from 250 patients with ocular infections visiting an ophthalmological clinic in southern Japan between 2011 and 2014. The results showed that conjunctival opacity, corneal epithelial disorders and pre-auricular lymphadenopathy, were more frequently associated with EKC than other ocular infections. Furthermore, HAdV types 8, 37 and 54, caused corneal complications and longer infections significantly more frequently than infections by types 53 and 56 (P < 0.05). Our descriptive results supported that symptoms severity vary with the infecting type, however, further research is needed to improve diagnosis of EKC.

本文言語英語
論文番号114885
ジャーナルDiagnostic Microbiology and Infectious Disease
95
4
DOI
出版ステータス出版済み - 12 2019
外部発表はい

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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