Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography

Yasuka Kikuchi, Masanao Naya, Noriko Oyama Manabe, Osamu Manabe, Hiroyuki Sugimori, Kohsuke Kudo, Fumi Kato, Tadao Aikawa, Hiroyuki Tsutsui, Nagara Tamaki, Hiroki Shirato

研究成果: ジャーナルへの寄稿記事

抄録

Purpose: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by 15O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. Methods: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. Results: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. Conclusion: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.

元の言語英語
ページ(範囲)134-141
ページ数8
ジャーナルMagnetic Resonance in Medical Sciences
18
発行部数2
DOI
出版物ステータス出版済み - 1 1 2019

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Positron-Emission Tomography
Coronary Artery Disease
Water
Arteries
Contrast Media
Area Under Curve
Magnetic Resonance Imaging
Radiation

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T : Comparison with 15O-labeled water positron emission tomography. / Kikuchi, Yasuka; Naya, Masanao; Manabe, Noriko Oyama; Manabe, Osamu; Sugimori, Hiroyuki; Kudo, Kohsuke; Kato, Fumi; Aikawa, Tadao; Tsutsui, Hiroyuki; Tamaki, Nagara; Shirato, Hiroki.

:: Magnetic Resonance in Medical Sciences, 巻 18, 番号 2, 01.01.2019, p. 134-141.

研究成果: ジャーナルへの寄稿記事

Kikuchi, Yasuka ; Naya, Masanao ; Manabe, Noriko Oyama ; Manabe, Osamu ; Sugimori, Hiroyuki ; Kudo, Kohsuke ; Kato, Fumi ; Aikawa, Tadao ; Tsutsui, Hiroyuki ; Tamaki, Nagara ; Shirato, Hiroki. / Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T : Comparison with 15O-labeled water positron emission tomography. :: Magnetic Resonance in Medical Sciences. 2019 ; 巻 18, 番号 2. pp. 134-141.
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abstract = "Purpose: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by 15O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. Methods: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. Results: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. Conclusion: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.",
author = "Yasuka Kikuchi and Masanao Naya and Manabe, {Noriko Oyama} and Osamu Manabe and Hiroyuki Sugimori and Kohsuke Kudo and Fumi Kato and Tadao Aikawa and Hiroyuki Tsutsui and Nagara Tamaki and Hiroki Shirato",
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T1 - Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T

T2 - Comparison with 15O-labeled water positron emission tomography

AU - Kikuchi, Yasuka

AU - Naya, Masanao

AU - Manabe, Noriko Oyama

AU - Manabe, Osamu

AU - Sugimori, Hiroyuki

AU - Kudo, Kohsuke

AU - Kato, Fumi

AU - Aikawa, Tadao

AU - Tsutsui, Hiroyuki

AU - Tamaki, Nagara

AU - Shirato, Hiroki

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by 15O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. Methods: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. Results: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. Conclusion: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.

AB - Purpose: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by 15O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. Methods: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. Results: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R2 = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. Conclusion: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material.

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