Assessment of Sarcopenia as a Predictor of Poor Outcomes after Esophagectomy in Elderly Patients with Esophageal Cancer

Yuichiro Nakashima, Hiroshi Saeki, Ryota Nakanishi, Masahiko Sugiyama, Junji Kurashige, Eiji Oki, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

抄録

Objective: The objective of the study was to elucidate the impact of sarcopenia in elderly patients with esophageal cancer on postoperative complications and long-term survival after surgery for esophageal cancer. Summary Background Data: Sarcopenia, defined as loss of skeletal muscle mass with age, has been identified as a poor prognostic factor for malignancies. This retrospective study investigated the effect of sarcopenia on surgical outcomes among young and elderly patients with esophageal cancer. Methods: Data were collected for 341 consecutive patients who underwent esophagectomy for esophageal cancer. Patients were assigned to 2 groups according to age (younger than 65 years and 65 years or older) and the presence of sarcopenia. Results: Sarcopenia was present in 170 of 341 patients (49.9%) with esophageal cancer and in 74 of 166 elderly patients (44.6%). The incidence of anastomotic leak and in-hospital death was significantly higher in the elderly sarcopenia group than in the elderly nonsarcopenia group (31.5% vs 15.2%, P = 0.015, 6.8 vs 0.0%, P = 0.037, respectively), and the overall survival rate in patients with sarcopenia correlated with a significantly poor prognosis in the elderly group (P < 0.001). Multivariate analysis revealed that sarcopenia was a risk factor for an anastomotic leak (P = 0.034) and was an unfavorable prognostic factor for survival (P < 0.001). Those correlations between sarcopenia and surgical outcomes were not observed in the young group. Conclusions: Sarcopenia and worse surgical outcomes were significantly associated patients with in esophageal cancer aged 65 years and older but not in those younger than 65 years.

元の言語英語
ページ(範囲)1100-1104
ページ数5
ジャーナルAnnals of Surgery
267
発行部数6
DOI
出版物ステータス出版済み - 6 1 2018

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Sarcopenia
Esophagectomy
Esophageal Neoplasms
Anastomotic Leak
Survival
Skeletal Muscle
Multivariate Analysis
Survival Rate
Retrospective Studies

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Assessment of Sarcopenia as a Predictor of Poor Outcomes after Esophagectomy in Elderly Patients with Esophageal Cancer. / Nakashima, Yuichiro; Saeki, Hiroshi; Nakanishi, Ryota; Sugiyama, Masahiko; Kurashige, Junji; Oki, Eiji; Maehara, Yoshihiko.

:: Annals of Surgery, 巻 267, 番号 6, 01.06.2018, p. 1100-1104.

研究成果: ジャーナルへの寄稿記事

Nakashima, Yuichiro ; Saeki, Hiroshi ; Nakanishi, Ryota ; Sugiyama, Masahiko ; Kurashige, Junji ; Oki, Eiji ; Maehara, Yoshihiko. / Assessment of Sarcopenia as a Predictor of Poor Outcomes after Esophagectomy in Elderly Patients with Esophageal Cancer. :: Annals of Surgery. 2018 ; 巻 267, 番号 6. pp. 1100-1104.
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abstract = "Objective: The objective of the study was to elucidate the impact of sarcopenia in elderly patients with esophageal cancer on postoperative complications and long-term survival after surgery for esophageal cancer. Summary Background Data: Sarcopenia, defined as loss of skeletal muscle mass with age, has been identified as a poor prognostic factor for malignancies. This retrospective study investigated the effect of sarcopenia on surgical outcomes among young and elderly patients with esophageal cancer. Methods: Data were collected for 341 consecutive patients who underwent esophagectomy for esophageal cancer. Patients were assigned to 2 groups according to age (younger than 65 years and 65 years or older) and the presence of sarcopenia. Results: Sarcopenia was present in 170 of 341 patients (49.9{\%}) with esophageal cancer and in 74 of 166 elderly patients (44.6{\%}). The incidence of anastomotic leak and in-hospital death was significantly higher in the elderly sarcopenia group than in the elderly nonsarcopenia group (31.5{\%} vs 15.2{\%}, P = 0.015, 6.8 vs 0.0{\%}, P = 0.037, respectively), and the overall survival rate in patients with sarcopenia correlated with a significantly poor prognosis in the elderly group (P < 0.001). Multivariate analysis revealed that sarcopenia was a risk factor for an anastomotic leak (P = 0.034) and was an unfavorable prognostic factor for survival (P < 0.001). Those correlations between sarcopenia and surgical outcomes were not observed in the young group. Conclusions: Sarcopenia and worse surgical outcomes were significantly associated patients with in esophageal cancer aged 65 years and older but not in those younger than 65 years.",
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AU - Nakashima, Yuichiro

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AU - Sugiyama, Masahiko

AU - Kurashige, Junji

AU - Oki, Eiji

AU - Maehara, Yoshihiko

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N2 - Objective: The objective of the study was to elucidate the impact of sarcopenia in elderly patients with esophageal cancer on postoperative complications and long-term survival after surgery for esophageal cancer. Summary Background Data: Sarcopenia, defined as loss of skeletal muscle mass with age, has been identified as a poor prognostic factor for malignancies. This retrospective study investigated the effect of sarcopenia on surgical outcomes among young and elderly patients with esophageal cancer. Methods: Data were collected for 341 consecutive patients who underwent esophagectomy for esophageal cancer. Patients were assigned to 2 groups according to age (younger than 65 years and 65 years or older) and the presence of sarcopenia. Results: Sarcopenia was present in 170 of 341 patients (49.9%) with esophageal cancer and in 74 of 166 elderly patients (44.6%). The incidence of anastomotic leak and in-hospital death was significantly higher in the elderly sarcopenia group than in the elderly nonsarcopenia group (31.5% vs 15.2%, P = 0.015, 6.8 vs 0.0%, P = 0.037, respectively), and the overall survival rate in patients with sarcopenia correlated with a significantly poor prognosis in the elderly group (P < 0.001). Multivariate analysis revealed that sarcopenia was a risk factor for an anastomotic leak (P = 0.034) and was an unfavorable prognostic factor for survival (P < 0.001). Those correlations between sarcopenia and surgical outcomes were not observed in the young group. Conclusions: Sarcopenia and worse surgical outcomes were significantly associated patients with in esophageal cancer aged 65 years and older but not in those younger than 65 years.

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