Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor

Joji Ishikawa, Motohiro Shimizu, Eijiro Sugiyama Edison, Yuichiro Yano, Satoshi Hoshide, Kauzo Eguchi, Kazuomi Kario

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.

元の言語英語
ページ(範囲)82-89
ページ数8
ジャーナルJournal of Hypertension
32
発行部数1
DOI
出版物ステータス出版済み - 1 1 2014

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Blood Pressure Monitors
Ambulatory Blood Pressure Monitoring
Antihypertensive Agents
Blood Pressure
Sodium Chloride Symporter Inhibitors
Ambulatory Monitoring
Left Ventricular Hypertrophy
Reading
Japan

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

これを引用

Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. / Ishikawa, Joji; Shimizu, Motohiro; Sugiyama Edison, Eijiro; Yano, Yuichiro; Hoshide, Satoshi; Eguchi, Kauzo; Kario, Kazuomi.

:: Journal of Hypertension, 巻 32, 番号 1, 01.01.2014, p. 82-89.

研究成果: ジャーナルへの寄稿記事

Ishikawa, Joji ; Shimizu, Motohiro ; Sugiyama Edison, Eijiro ; Yano, Yuichiro ; Hoshide, Satoshi ; Eguchi, Kauzo ; Kario, Kazuomi. / Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. :: Journal of Hypertension. 2014 ; 巻 32, 番号 1. pp. 82-89.
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abstract = "BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.",
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T1 - Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor

AU - Ishikawa, Joji

AU - Shimizu, Motohiro

AU - Sugiyama Edison, Eijiro

AU - Yano, Yuichiro

AU - Hoshide, Satoshi

AU - Eguchi, Kauzo

AU - Kario, Kazuomi

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N2 - BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.

AB - BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4±17.9/6.0±12.0 vs. 13.3±14.6/7.6±8.9mmHg, P=0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r=0.51/0.38, P<0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r=0.385, P=0.013, N=41) and Sokolow-Lyon voltage (r=0.335, P=0.035, N=40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.

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