抄録
Immune responsiveness to schistosomal worm antigen was investigated in the individuals infected with Schistosoma japonicum by measuring the antigen-specific proliferative response of the peripheral T lymphocytes in vitro. Out of 57 infected individuals, 10 (17.5%) were low responders, whereas 47 (82.5%) were high responders to this antigen. The strong association between the HLA-Aw24-Bw52-DwI2 haplotype and the low responder group was demonstrated. Because the association of the low responder group was strongest with the HLA-D specificity, Dw12, and because the HLA-D region was assumed to be comparable to the I region of the murine H-2 complex, it was suggested that the low responsiveness to schistosomal worm antigen was controlled by a single dominant imune suppresssion gene that was in strong linkage disequilibrium with HLA-Dw12.
本文言語 | 英語 |
---|---|
ページ(範囲) | 314-318 |
ページ数 | 5 |
ジャーナル | Journal of Experimental Medicine |
巻 | 152 |
号 | 2 II |
出版ステータス | 出版済み - 1980 |
外部発表 | はい |
!!!All Science Journal Classification (ASJC) codes
- 免疫アレルギー学
- 免疫学