Association between an HLA haplotype and low responsiveness to tetanus toxoid in man

T. Sasazuki; Y. Kohno; I. Iwamoto; M. Tanimura; S. Naito

doi:10.1038/272359b0

Association between an HLA haplotype and low responsiveness to tetanus toxoid in man

T. Sasazuki, Y. Kohno, I. Iwamoto, M. Tanimura, S. Naito

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

3 被引用数 (Scopus)

抄録

THE major histocompatibility complex (MHC) in man, the HLA gene complex, has been assumed to code not only for histocompatibility antigens but also for immune responsiveness and control of disease susceptibility¹. Although several attempts have been made to delineate the existence of HLA-linked immune response genes (Ir genes) in man, the data are controversial^2-6. We demonstrate here a striking association between a particular HLA haplotype and low responsiveness to tetanus toxoid in vitro, which suggests that immune suppression genes exist in man.

本文言語	英語
ページ数	1
ジャーナル	Nature
巻	272
号	5651
DOI	https://doi.org/10.1038/272359b0
出版ステータス	出版済み - 12月 1 1978
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

一般

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10.1038/272359b0

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AU - Naito, S.

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Association between an HLA haplotype and low responsiveness to tetanus toxoid in man

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