Association between an HLA haplotype and low responsiveness to tetanus toxoid in man

T. Sasazuki, Y. Kohno, I. Iwamoto, M. Tanimura, S. Naito

研究成果: Contribution to journalArticle査読

64 被引用数 (Scopus)

抄録

THE major histocompatibility complex (MHC) in man, the HLA gene complex, has been assumed to code not only for histocompatibility antigens but also for immune responsiveness and control of disease susceptibility1. Although several attempts have been made to delineate the existence of HLA-linked immune response genes (Ir genes) in man, the data are controversial2-6. We demonstrate here a striking association between a particular HLA haplotype and low responsiveness to tetanus toxoid in vitro, which suggests that immune suppression genes exist in man.

本文言語英語
ページ数1
ジャーナルNature
272
5651
DOI
出版ステータス出版済み - 12 1 1978
外部発表はい

All Science Journal Classification (ASJC) codes

  • 一般

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