Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment: The Japan Morning Surge-Target Organ Protection (J-TOP) study

Motohiro Shimizu, Joji Ishikawa, Yuichiro Yano, Satoshi Hoshide, Kazuo Eguchi, Shizukiyo Ishikawa, Kazuyuki Shimada, Kazuomi Kario

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

抄録

Background: Asleep blood pressure (BP) has been shown to better reflect cardiovascular risk than awake BP in hypertensive patients. This study investigated the correlation of brain natriuretic peptide (BNP) to asleep BP during antihypertensive treatment. Methods: In the Japan Morning Surge-Target Organ Protection (J-TOP) study, which was an open-label multicenter trial to compare bedtime or awakening dosing of candesartan (+ diuretics as needed) among individuals with home SBP higher than 135 mmHg, we evaluated 254 hypertensive patients who underwent ambulatory BP monitoring, and measured their BNP at baseline and after 6th month of treatment. Results: At follow-up, the decrease in log-transformed BNP was significantly related to the decrease in asleep SBP (r = 0.27, P < 0.001); the relationship remained significant (β = 0.20, P = 0.002) even after adjusting for the decrease in the awake SBP (β = 0.001, P = 0.991). When we divided participants by their time of candesartan administration, the relationship between the decrease in log-transformed BNP and asleep SBP was still significant in both the awakening-dosing group (β = 0.21, P = 0.028) and the bedtime-dosing group (β = 0.21, P = 0.029). Furthermore, this relationship was strong in the participants who were receiving diuretics. Conclusion: The decrease in BNP is associated with asleep BP reduction by candesartan (+ diuretics as needed) over and above the awake BP reduction, regardless of the time of administration.

元の言語英語
ページ(範囲)1015-1021
ページ数7
ジャーナルJournal of Hypertension
30
発行部数5
DOI
出版物ステータス出版済み - 5 1 2012

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Brain Natriuretic Peptide
Antihypertensive Agents
Japan
Blood Pressure
Diuretics
Therapeutics
Ambulatory Blood Pressure Monitoring
Multicenter Studies
candesartan

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

これを引用

Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment : The Japan Morning Surge-Target Organ Protection (J-TOP) study. / Shimizu, Motohiro; Ishikawa, Joji; Yano, Yuichiro; Hoshide, Satoshi; Eguchi, Kazuo; Ishikawa, Shizukiyo; Shimada, Kazuyuki; Kario, Kazuomi.

:: Journal of Hypertension, 巻 30, 番号 5, 01.05.2012, p. 1015-1021.

研究成果: ジャーナルへの寄稿記事

Shimizu, Motohiro ; Ishikawa, Joji ; Yano, Yuichiro ; Hoshide, Satoshi ; Eguchi, Kazuo ; Ishikawa, Shizukiyo ; Shimada, Kazuyuki ; Kario, Kazuomi. / Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment : The Japan Morning Surge-Target Organ Protection (J-TOP) study. :: Journal of Hypertension. 2012 ; 巻 30, 番号 5. pp. 1015-1021.
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abstract = "Background: Asleep blood pressure (BP) has been shown to better reflect cardiovascular risk than awake BP in hypertensive patients. This study investigated the correlation of brain natriuretic peptide (BNP) to asleep BP during antihypertensive treatment. Methods: In the Japan Morning Surge-Target Organ Protection (J-TOP) study, which was an open-label multicenter trial to compare bedtime or awakening dosing of candesartan (+ diuretics as needed) among individuals with home SBP higher than 135 mmHg, we evaluated 254 hypertensive patients who underwent ambulatory BP monitoring, and measured their BNP at baseline and after 6th month of treatment. Results: At follow-up, the decrease in log-transformed BNP was significantly related to the decrease in asleep SBP (r = 0.27, P < 0.001); the relationship remained significant (β = 0.20, P = 0.002) even after adjusting for the decrease in the awake SBP (β = 0.001, P = 0.991). When we divided participants by their time of candesartan administration, the relationship between the decrease in log-transformed BNP and asleep SBP was still significant in both the awakening-dosing group (β = 0.21, P = 0.028) and the bedtime-dosing group (β = 0.21, P = 0.029). Furthermore, this relationship was strong in the participants who were receiving diuretics. Conclusion: The decrease in BNP is associated with asleep BP reduction by candesartan (+ diuretics as needed) over and above the awake BP reduction, regardless of the time of administration.",
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T1 - Association between asleep blood pressure and brain natriuretic peptide during antihypertensive treatment

T2 - The Japan Morning Surge-Target Organ Protection (J-TOP) study

AU - Shimizu, Motohiro

AU - Ishikawa, Joji

AU - Yano, Yuichiro

AU - Hoshide, Satoshi

AU - Eguchi, Kazuo

AU - Ishikawa, Shizukiyo

AU - Shimada, Kazuyuki

AU - Kario, Kazuomi

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N2 - Background: Asleep blood pressure (BP) has been shown to better reflect cardiovascular risk than awake BP in hypertensive patients. This study investigated the correlation of brain natriuretic peptide (BNP) to asleep BP during antihypertensive treatment. Methods: In the Japan Morning Surge-Target Organ Protection (J-TOP) study, which was an open-label multicenter trial to compare bedtime or awakening dosing of candesartan (+ diuretics as needed) among individuals with home SBP higher than 135 mmHg, we evaluated 254 hypertensive patients who underwent ambulatory BP monitoring, and measured their BNP at baseline and after 6th month of treatment. Results: At follow-up, the decrease in log-transformed BNP was significantly related to the decrease in asleep SBP (r = 0.27, P < 0.001); the relationship remained significant (β = 0.20, P = 0.002) even after adjusting for the decrease in the awake SBP (β = 0.001, P = 0.991). When we divided participants by their time of candesartan administration, the relationship between the decrease in log-transformed BNP and asleep SBP was still significant in both the awakening-dosing group (β = 0.21, P = 0.028) and the bedtime-dosing group (β = 0.21, P = 0.029). Furthermore, this relationship was strong in the participants who were receiving diuretics. Conclusion: The decrease in BNP is associated with asleep BP reduction by candesartan (+ diuretics as needed) over and above the awake BP reduction, regardless of the time of administration.

AB - Background: Asleep blood pressure (BP) has been shown to better reflect cardiovascular risk than awake BP in hypertensive patients. This study investigated the correlation of brain natriuretic peptide (BNP) to asleep BP during antihypertensive treatment. Methods: In the Japan Morning Surge-Target Organ Protection (J-TOP) study, which was an open-label multicenter trial to compare bedtime or awakening dosing of candesartan (+ diuretics as needed) among individuals with home SBP higher than 135 mmHg, we evaluated 254 hypertensive patients who underwent ambulatory BP monitoring, and measured their BNP at baseline and after 6th month of treatment. Results: At follow-up, the decrease in log-transformed BNP was significantly related to the decrease in asleep SBP (r = 0.27, P < 0.001); the relationship remained significant (β = 0.20, P = 0.002) even after adjusting for the decrease in the awake SBP (β = 0.001, P = 0.991). When we divided participants by their time of candesartan administration, the relationship between the decrease in log-transformed BNP and asleep SBP was still significant in both the awakening-dosing group (β = 0.21, P = 0.028) and the bedtime-dosing group (β = 0.21, P = 0.029). Furthermore, this relationship was strong in the participants who were receiving diuretics. Conclusion: The decrease in BNP is associated with asleep BP reduction by candesartan (+ diuretics as needed) over and above the awake BP reduction, regardless of the time of administration.

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