TY - JOUR
T1 - Association between Axial Length and Myopic Maculopathy
T2 - The Hisayama Study
AU - Hashimoto, Sawako
AU - Yasuda, Miho
AU - Fujiwara, Kohta
AU - Ueda, Emi
AU - Hata, Jun
AU - Hirakawa, Yoichiro
AU - Ninomiya, Toshiharu
AU - Sonoda, Koh hei
N1 - Funding Information:
Supported by the Ministry of Education, Culture, Sports, Science and Technology of Japan, Tokyo, Japan (Grants-in-Aid for Scientific Research nos.: JP16H02644 and JP16H02692; JP16H05850, JP16H05557, JP17H04126, and JP18H02737; JP16K09244, JP17K09114, JP17K09113, JP17K01853, JP18K07565, and JP18K09412; and Early-Career Scientists awards JP18K17925, JP18K17382, and JP18K16960); the Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan, Tokyo, Japan (grant nos.: H29-Junkankitou-Ippan-003 and H30-Shokuhin-[Sitei]-005); the Japan Agency for Medical Research and Development, Tokyo, Japan (grant nos.: JP18dk0207025, JP18ek0210082, JP18gm0610007, JP18ek0210083, JP18km0405202, JP18ek0210080, and JP18fk0108075). The sponsor or funding organizations had no role in the design or conduct of this research. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Obtained funding: Yasuda, Fujiwara, Ninomiya
PY - 2019/10
Y1 - 2019/10
N2 - Purpose: To assess the association between axial length (AL) and the prevalence of myopic maculopathy in a general Japanese population. Design: Population-based cross-sectional study. Participants: A total of 2790 Hisayama residents 40 years of age or older who consented to participate and had available data of AL and fundus photographs for the right eyes were enrolled in this study. Methods: Myopic maculopathy was defined as the presence of diffuse chorioretinal atrophy, patchy chorioretinal atrophy, or macular degeneration. The optimal cutoff values of axial length for identifying myopic maculopathy were estimated from the receiver operating characteristic curve. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a logistic regression analysis. Main Outcome Measures: Odds ratios of AL for prevalent myopic maculopathy and the optimal cutoff values of AL for detecting myopic maculopathy. Results: Longer AL was associated significantly with prevalence of myopic maculopathy in both genders. The optimal cutoff values of AL for identifying myopic maculopathy were 25.9 mm in men and 25.3 mm in women. Participants with ALs of these values or longer showed a significantly higher OR for myopic maculopathy than those with AL of less than these values (men: OR, 21.23; 95% CI, 8.74–51.57; women: OR, 38.49; 95% CI, 18.03–86.49). Conclusions: The present study found that there was a positive association between AL and the likelihood of myopic maculopathy, and the cutoff levels of AL for identifying myopic maculopathy were 25.9 mm in men and 25.3 mm in women. Our findings suggest that patients with AL close to or longer than these values should undergo intensive treatment and detailed ophthalmic follow-up.
AB - Purpose: To assess the association between axial length (AL) and the prevalence of myopic maculopathy in a general Japanese population. Design: Population-based cross-sectional study. Participants: A total of 2790 Hisayama residents 40 years of age or older who consented to participate and had available data of AL and fundus photographs for the right eyes were enrolled in this study. Methods: Myopic maculopathy was defined as the presence of diffuse chorioretinal atrophy, patchy chorioretinal atrophy, or macular degeneration. The optimal cutoff values of axial length for identifying myopic maculopathy were estimated from the receiver operating characteristic curve. The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using a logistic regression analysis. Main Outcome Measures: Odds ratios of AL for prevalent myopic maculopathy and the optimal cutoff values of AL for detecting myopic maculopathy. Results: Longer AL was associated significantly with prevalence of myopic maculopathy in both genders. The optimal cutoff values of AL for identifying myopic maculopathy were 25.9 mm in men and 25.3 mm in women. Participants with ALs of these values or longer showed a significantly higher OR for myopic maculopathy than those with AL of less than these values (men: OR, 21.23; 95% CI, 8.74–51.57; women: OR, 38.49; 95% CI, 18.03–86.49). Conclusions: The present study found that there was a positive association between AL and the likelihood of myopic maculopathy, and the cutoff levels of AL for identifying myopic maculopathy were 25.9 mm in men and 25.3 mm in women. Our findings suggest that patients with AL close to or longer than these values should undergo intensive treatment and detailed ophthalmic follow-up.
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U2 - 10.1016/j.oret.2019.04.023
DO - 10.1016/j.oret.2019.04.023
M3 - Article
AN - SCOPUS:85072589425
VL - 3
SP - 867
EP - 873
JO - Ophthalmology Retina
JF - Ophthalmology Retina
SN - 2468-7219
IS - 10
ER -