Association between chronic hepatitis C virus infection and high levels of circulating N-terminal pro-brain natriuretic peptide

Kyoko Okada, Norihiro Furusyo, Eiichi Ogawa, Hiroaki Ikezaki, Tsuyoshi Ihara, Takeo Hayashi, Mosaburo Kainuma, Murata Masayuki, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

The association between HCV infection and myocardial disorders remains unclear. This study aimed to assess whether or not HCV infection influences myocardial dysfunction by the use of NT-proBNP, a sensitive marker of myocardial dysfunction. A total of 198 participants [99 patients with chronic HCV infection (aged 46-68 years) and 99 anti-HCV-negative sex and age matched controls] were examined. Serum HCV-RNA level and HCV genotype were tested and liver biopsy was done only for the patient group. The NT-proBNP concentration of the HCV patients (mean 71.6 ± 79.1 pg/ml; median 46.0 pg/ml, range 5.0-400.0) was significantly higher than that of the controls (mean 39.8 ± 24.4 pg/ml; median 35.8 pg/ml, range 7.0-108.0) (P < 0.05). 20.0 % of the HCV patients and 0.6 % of the controls had high NT-proBNP (higher than 125 pg/ml; the single cut off point for patients under 75 years of age) (P < 0.05). Stepwise multiple regression analysis revealed that chronic HCV infection was independently correlated with NT-proBNP level after adjustment for parameters that might influence NT-proBNP (P = 0.005). Our data suggest that chronic HCV infection is associated with increased NT-proBNP, indicating that chronic HCV infection might induce myocardial dysfunction.

元の言語英語
ページ(範囲)200-205
ページ数6
ジャーナルEndocrine
43
発行部数1
DOI
出版物ステータス出版済み - 2 1 2013

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Brain Natriuretic Peptide
Chronic Hepatitis C
Virus Diseases
Hepacivirus
Infection
pro-brain natriuretic peptide (1-76)
Genotype
Regression Analysis
RNA
Biopsy
Liver
Serum

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

これを引用

Association between chronic hepatitis C virus infection and high levels of circulating N-terminal pro-brain natriuretic peptide. / Okada, Kyoko; Furusyo, Norihiro; Ogawa, Eiichi; Ikezaki, Hiroaki; Ihara, Tsuyoshi; Hayashi, Takeo; Kainuma, Mosaburo; Masayuki, Murata; Hayashi, Jun.

:: Endocrine, 巻 43, 番号 1, 01.02.2013, p. 200-205.

研究成果: ジャーナルへの寄稿記事

Okada, Kyoko ; Furusyo, Norihiro ; Ogawa, Eiichi ; Ikezaki, Hiroaki ; Ihara, Tsuyoshi ; Hayashi, Takeo ; Kainuma, Mosaburo ; Masayuki, Murata ; Hayashi, Jun. / Association between chronic hepatitis C virus infection and high levels of circulating N-terminal pro-brain natriuretic peptide. :: Endocrine. 2013 ; 巻 43, 番号 1. pp. 200-205.
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AU - Ihara, Tsuyoshi

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