TY - JOUR
T1 - Association between fever and serum interleukin-6 levels in children with group a β-hemolytic streptococcal infection
AU - Ohga, Shouichi
AU - Nishizaki, Mari
AU - Nagashima, Takako
AU - Ueda, Kohji
N1 - Funding Information:
This work was supported by a grant from the Ministry of Health and Welfare for Primary Immunodeficiency Dis-eases, and a grant-in-aid for the encouragement of young scientists from the Ministry of Education, Science and Culture of Japan.
PY - 1994/4
Y1 - 1994/4
N2 - 1. 1|The serum levels of interleukin (IL)-1β, IL-6 and granulocyte colony-stimulating factor (G-CSF) were measured in children with Group A β-hemolytic streptococcal (GABHS) infection using sensitive immunoassays. 2. 2|Serum IL-6 levels were elevated in 21 27 patients during the phase of GABHS antigen-detection, significantly higher than in healthy control children (P < 0.01). Levels of IL-1 were undetectable in all but one sample. 3. 3|The IL-6 level peaked on day 3 of the infection, then decreased. The IL-6 levels were significantly associated with the duration of fever (P < 0.05) and the maximum body temperature (BT) (P < 0.05), but not with the BT at time of blood sampling, C-reactive protein levels or leukocyte counts. 4. 4|Levels of G-CSF were slightly higher in the patients with infection than in the controls (P < 0.05), but were not correlated with any other parameter including neutrophil counts. 5. 5|These cytokine levels neither reflected a differing T-serotype infection, nor did they vary among patients with regard to the presence of skin eruptions and the carrier state. 6. 6|These observations suggest that IL-6, but not IL-1, is produced during the acute phase of GABHS infection, accounting for the febrile condition as an inflammatory cytokine, despite the serotype of the infecting organism or the clinical types of infection.
AB - 1. 1|The serum levels of interleukin (IL)-1β, IL-6 and granulocyte colony-stimulating factor (G-CSF) were measured in children with Group A β-hemolytic streptococcal (GABHS) infection using sensitive immunoassays. 2. 2|Serum IL-6 levels were elevated in 21 27 patients during the phase of GABHS antigen-detection, significantly higher than in healthy control children (P < 0.01). Levels of IL-1 were undetectable in all but one sample. 3. 3|The IL-6 level peaked on day 3 of the infection, then decreased. The IL-6 levels were significantly associated with the duration of fever (P < 0.05) and the maximum body temperature (BT) (P < 0.05), but not with the BT at time of blood sampling, C-reactive protein levels or leukocyte counts. 4. 4|Levels of G-CSF were slightly higher in the patients with infection than in the controls (P < 0.05), but were not correlated with any other parameter including neutrophil counts. 5. 5|These cytokine levels neither reflected a differing T-serotype infection, nor did they vary among patients with regard to the presence of skin eruptions and the carrier state. 6. 6|These observations suggest that IL-6, but not IL-1, is produced during the acute phase of GABHS infection, accounting for the febrile condition as an inflammatory cytokine, despite the serotype of the infecting organism or the clinical types of infection.
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U2 - 10.1016/0306-4565(94)90055-8
DO - 10.1016/0306-4565(94)90055-8
M3 - Article
AN - SCOPUS:0028154381
VL - 19
SP - 91
EP - 96
JO - Journal of Thermal Biology
JF - Journal of Thermal Biology
SN - 0306-4565
IS - 2
ER -