Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk: a case–control study in Japan

Yuzo Yamamoto, Chikako Kiyohara, Saiko Ogata-Suetsugu, Naoki Hamada, Yoichi Nakanishi

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

抄録

Aim: Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway. Methods: This case–control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined. Results: The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30–0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24–0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant. Conclusion: HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results.

元の言語英語
ページ(範囲)234-242
ページ数9
ジャーナルAsia-Pacific Journal of Clinical Oncology
13
発行部数3
DOI
出版物ステータス出版済み - 6 1 2017

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Genetic Polymorphisms
Lung Neoplasms
Japan
Vascular Endothelial Growth Factor A
Smoking
Odds Ratio
Confidence Intervals
Genotype
Social Adjustment
Hypoxia
Real-Time Polymerase Chain Reaction
Neoplasms
Logistic Models

All Science Journal Classification (ASJC) codes

  • Oncology

これを引用

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title = "Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk: a case–control study in Japan",
abstract = "Aim: Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway. Methods: This case–control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95{\%} confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined. Results: The AA genotype of HIF2A rs13419896 (OR = 0.54, 95{\%} CI = 0.30–0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95{\%} CI = 0.24–0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant. Conclusion: HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results.",
author = "Yuzo Yamamoto and Chikako Kiyohara and Saiko Ogata-Suetsugu and Naoki Hamada and Yoichi Nakanishi",
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TY - JOUR

T1 - Association between genetic polymorphisms involved in the hypoxia-inducible factor pathway and lung cancer risk

T2 - a case–control study in Japan

AU - Yamamoto, Yuzo

AU - Kiyohara, Chikako

AU - Ogata-Suetsugu, Saiko

AU - Hamada, Naoki

AU - Nakanishi, Yoichi

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Aim: Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway. Methods: This case–control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined. Results: The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30–0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24–0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant. Conclusion: HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results.

AB - Aim: Hypoxia-inducible factor (HIF) contributes to the adaptation of tumor cells to hypoxic conditions, so genetic polymorphisms involved in this pathway may affect cellular response to hypoxia and be associated with cancer risk. Thus, we examined the association between the lung cancer risk and genetic polymorphisms involved in the HIF pathway. Methods: This case–control study consists of 462 lung cancer cases and 379 controls from Japan. We examined the effect of HIF1A rs11549467, HIF1A rs11549465, HIF1A rs2057482, HIF2A rs13419896 and vascular endothelial growth factor A (VEGFA) rs833061 on the risk of lung cancer using TaqMan real-time PCR assay. Logistic regression was used to estimate the odds ratio (OR) and its 95% confidence interval (CI) of lung cancer risk. The multiplicative and additive interactions with cigarette smoking were also examined. Results: The AA genotype of HIF2A rs13419896 (OR = 0.54, 95% CI = 0.30–0.99) and the CC genotype of VEGFA rs833061 (OR = 0.42, 95% CI = 0.24–0.75) were significantly associated with a decreased risk of lung cancer after adjustment of potential covariates. Additive interactions between these two polymorphisms and cigarette smoking were also significant. Conclusion: HIF2A rs13419896 and VEGFA rs833061 were significantly related to lung cancer risk, with possible interaction between polymorphisms and cigarette smoking. Further studies are needed to confirm these results.

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JO - Asia-Pacific Journal of Clinical Oncology

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