Association between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer

Kazuki Takada, Gouji Toyokawa, Tetsuzo Tagawa, Kenichi Kohashi, Takaki Akamine, Shinkichi Takamori, Fumihiko Hirai, Fumihiro Shoji, Tatsuro Okamoto, Yoshinao Oda, Yoshihiko Maehara

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

抄録

Aim: We evaluated the metabolic characteristics of small-sized lung cancer using 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) with regard to programmed cell death ligand 1 (PD-L1) expression. Materials and Methods: PD-L1 expression was evaluated by immunohistochemistry with the antibody clone SP142 in 263 patients with surgically resected primary small-sized lung cancer. Specimens with <5% tumor membrane staining were considered negative. We examined the association between the frequency of PD-L1 expression and the maximum standardized uptake value (SUVmax) in preoperative 18F-FDG PET/CT. Results: Among patients with non-small cell lung cancer (NSCLC), the SUVmax was significantly higher in those with PD-L1 expression than in those without (p<0.0001). However, there was no correlation between SUVmax and PD-L1 expression in patients with neuroendocrine tumors (p=0.9638). Multivariate analysis revealed that smoking and a high SUVmax were independent predictors of PD-L1 expression. Conclusion: PD-L1 expression was related to high glucose metabolism in small-sized NSCLC.

元の言語英語
ページ(範囲)7073-7082
ページ数10
ジャーナルAnticancer research
37
発行部数12
DOI
出版物ステータス出版済み - 1 1 2017

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Fluorodeoxyglucose F18
Lung Neoplasms
Cell Death
Ligands
Non-Small Cell Lung Carcinoma
Neuroendocrine Tumors
Multivariate Analysis
Clone Cells
Smoking
Immunohistochemistry
Staining and Labeling
Glucose
Membranes
Antibodies
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Association between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer. / Takada, Kazuki; Toyokawa, Gouji; Tagawa, Tetsuzo; Kohashi, Kenichi; Akamine, Takaki; Takamori, Shinkichi; Hirai, Fumihiko; Shoji, Fumihiro; Okamoto, Tatsuro; Oda, Yoshinao; Maehara, Yoshihiko.

:: Anticancer research, 巻 37, 番号 12, 01.01.2017, p. 7073-7082.

研究成果: ジャーナルへの寄稿記事

Takada, K, Toyokawa, G, Tagawa, T, Kohashi, K, Akamine, T, Takamori, S, Hirai, F, Shoji, F, Okamoto, T, Oda, Y & Maehara, Y 2017, 'Association between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer', Anticancer research, 巻. 37, 番号 12, pp. 7073-7082. https://doi.org/10.21873/anticanres.12180
Takada, Kazuki ; Toyokawa, Gouji ; Tagawa, Tetsuzo ; Kohashi, Kenichi ; Akamine, Takaki ; Takamori, Shinkichi ; Hirai, Fumihiko ; Shoji, Fumihiro ; Okamoto, Tatsuro ; Oda, Yoshinao ; Maehara, Yoshihiko. / Association between PD-L1 Expression and Metabolic Activity on 18F-FDG PET/CT in Patients with Small-sized Lung Cancer. :: Anticancer research. 2017 ; 巻 37, 番号 12. pp. 7073-7082.
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author = "Kazuki Takada and Gouji Toyokawa and Tetsuzo Tagawa and Kenichi Kohashi and Takaki Akamine and Shinkichi Takamori and Fumihiko Hirai and Fumihiro Shoji and Tatsuro Okamoto and Yoshinao Oda and Yoshihiko Maehara",
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AU - Toyokawa, Gouji

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AU - Kohashi, Kenichi

AU - Akamine, Takaki

AU - Takamori, Shinkichi

AU - Hirai, Fumihiko

AU - Shoji, Fumihiro

AU - Okamoto, Tatsuro

AU - Oda, Yoshinao

AU - Maehara, Yoshihiko

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N2 - Aim: We evaluated the metabolic characteristics of small-sized lung cancer using 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (18F-FDG PET/CT) with regard to programmed cell death ligand 1 (PD-L1) expression. Materials and Methods: PD-L1 expression was evaluated by immunohistochemistry with the antibody clone SP142 in 263 patients with surgically resected primary small-sized lung cancer. Specimens with <5% tumor membrane staining were considered negative. We examined the association between the frequency of PD-L1 expression and the maximum standardized uptake value (SUVmax) in preoperative 18F-FDG PET/CT. Results: Among patients with non-small cell lung cancer (NSCLC), the SUVmax was significantly higher in those with PD-L1 expression than in those without (p<0.0001). However, there was no correlation between SUVmax and PD-L1 expression in patients with neuroendocrine tumors (p=0.9638). Multivariate analysis revealed that smoking and a high SUVmax were independent predictors of PD-L1 expression. Conclusion: PD-L1 expression was related to high glucose metabolism in small-sized NSCLC.

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