Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma

Kazuki Takada, Mototsugu Shimokawa, Kensuke Tanaka, Kenichi Kouhashi, Akira Haro, Atsushi Osoegawa, Tetsuzo Tagawa, Koichi Azuma, Isamu Okamoto, Yoshinao Oda, Masaki Mori

研究成果: ジャーナルへの寄稿記事

抄録

We sought to identify peripheral blood markers associated with two immune-related factors —programmed cell death-ligand-2 (PD-L2) and indoleamine 2,3-dioxygenase-1 (IDO1)—that are expressed on tumor cells in primary lung adenocarcinoma (AD) specimens. We randomly selected 448 patients (70%) from 640 consecutive patients with resected stage I–III primary lung AD, who had been treated at that point with surgery alone. Expression of PD-L2 and IDO1 in these patients was assessed by immunohistochemistry, and evaluated with respect to peripheral blood markers measured before surgery, including white blood cells, absolute neutrophil count, absolute lymphocyte count, absolute monocyte count (AMC), absolute eosinophil count (AEC), serum C-reactive protein, and serum lactate dehydrogenase levels. Membrane PD-L2 expression and cytoplasmic IDO1 expression were defined by tumor proportion score (TPS); samples with TPS < 1% were considered negative. Logistic regression models were used to identify variables associated with the immune-related factors. Advanced stage (P = 0.0090), higher AMC (P = 0.0195), and higher AEC (P = 0.0015) were independent predictors of IDO1 expression. PD-L2 expression was not associated with any tested peripheral blood markers. Peripheral blood markers, especially AMC and AEC, could potential predict IDO1 expression in lung AD. This study should be replicated in another cohort; further efforts to explore other biomarkers that predict PD-L2 or IDO1 expression are also warranted.

元の言語英語
記事番号e0217991
ジャーナルPloS one
14
発行部数6
DOI
出版物ステータス出版済み - 6 1 2019

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Indoleamine-Pyrrole 2,3,-Dioxygenase
Immunologic Factors
adenocarcinoma
Cell death
Tumors
Blood
lungs
Cells
Cell Death
apoptosis
Ligands
blood
eosinophils
Eosinophils
monocytes
Monocytes
Neoplasms
Surgery
surgery
Logistic Models

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

これを引用

Association between peripheral blood markers and immune-related factors on tumor cells in patients with resected primary lung adenocarcinoma. / Takada, Kazuki; Shimokawa, Mototsugu; Tanaka, Kensuke; Kouhashi, Kenichi; Haro, Akira; Osoegawa, Atsushi; Tagawa, Tetsuzo; Azuma, Koichi; Okamoto, Isamu; Oda, Yoshinao; Mori, Masaki.

:: PloS one, 巻 14, 番号 6, e0217991, 01.06.2019.

研究成果: ジャーナルへの寄稿記事

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