Association between plasma levels of homocysteine, folate, and vitamin B12, and dietary folate intake and hypertension in a cross-sectional study

Takashi Tamura, Nagato Kuriyama, Teruhide Koyama, Etsuko Ozaki, Daisuke Matsui, Yuka Kadomatsu, Mineko Tsukamoto, Yoko Kubo, Rieko Okada, Asahi Hishida, Tae Sasakabe, Sayo Kawai, Mariko Naito, Naoyuki Takashima, Aya Kadota, Keitaro Tanaka, Megumi Hara, Sadao Suzuki, Hiroko Nakagawa-Senda, Toshiro TakezakiIppei Shimoshikiryo, Hiroaki Ikezaki, Masayuki Murata, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kiyonori Kuriki, Kokichi Arisawa, Hirokazu Uemura, Kenji Takeuchi, Kenji Wakai

研究成果: Contribution to journalArticle査読

抄録

There are few studies examining the association between homocysteine (Hcy) level and the risk of hypertension with consideration for folate and vitamin B12 as related to Hcy level. We simultaneously examined the associations of plasma levels of Hcy, folate, and vitamin B12, and dietary folate intake with the prevalence of hypertension. Participants included 1046 men and 1033 women (mean age ± standard deviation: 56.0 ± 8.9 years) in the Japan Multi-Institutional Collaborative Cohort Study. Dietary folate intake was estimated using a validated food frequency questionnaire. Hypertension was defined based on measured blood pressure and use of antihypertensive medication. A total of 734 participants (35.3%) had hypertension. Multivariate-adjusted odds ratios of hypertension for the highest quartile group of Hcy were 2.36 (95% CI 1.41–3.96) in men and 1.86 (95% CI 1.11–3.11) in women, as compared with the lowest group (P for trend = 0.014 and 0.005, respectively). Dietary folate intake was not correlated with hypertension in both men and women (P for trend = 0.099 and 0.703, respectively). Plasma vitamin B12 was positively associated with hypertension only in women (P for trend = 0.027). Plasma Hcy level was positively linked with hypertension after controlling for covariates, including folate and vitamin B12.

本文言語英語
論文番号18499
ジャーナルScientific reports
10
1
DOI
出版ステータス出版済み - 12 1 2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • General

フィンガープリント 「Association between plasma levels of homocysteine, folate, and vitamin B<sub>12</sub>, and dietary folate intake and hypertension in a cross-sectional study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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