Association between restriction fragment length polymorphism of the L- myc gene and susceptibility to gastric cancer

K. Shibuta, Masaki Mori, M. Haraguchi, K. Yoshikawa, H. Ueo, T. Akiyoshi

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

抄録

Background: L-myc polymorphism has been documented to be a representative genetic trait which is related an individual's susceptibility to several cancers. However, there have been no reports concerning any significant association between susceptibility to gastric cancer and L-myc polymorphism. Methods: The distribution of L-myc polymorphism in 61 patients with gastric cancer was determined by polymerase chain reaction-based restriction fragment length polymorphism and compared with that of 107 healthy control subjects. Results: There was a significant difference in the distribution of both genotypes (P = 0.024) and allele frequencies (P = 0.026) between the two groups. The relative risk of gastric cancer for genotypes with the shorter (S) allele was 3.09 compared with the longer (L) allele homozygote. No significant correlation with clinicopathological features of the cancers except for prognosis was found. The patients with SS genotypes had a worse prognosis than those with LL or LS genotypes (P = 0.029). Conclusion: L-myc polymorphism may be significant in an individual's susceptibility to gastric cancer in Japan, and may be a useful marker for identifying patients at high risk of developing gastric cancer.

元の言語英語
ページ(範囲)681-684
ページ数4
ジャーナルBritish Journal of Surgery
85
発行部数5
DOI
出版物ステータス出版済み - 6 10 1998

Fingerprint

myc Genes
Restriction Fragment Length Polymorphisms
Stomach Neoplasms
Genotype
Alleles
Homozygote
Gene Frequency
Neoplasms
Healthy Volunteers
Japan
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Association between restriction fragment length polymorphism of the L- myc gene and susceptibility to gastric cancer. / Shibuta, K.; Mori, Masaki; Haraguchi, M.; Yoshikawa, K.; Ueo, H.; Akiyoshi, T.

:: British Journal of Surgery, 巻 85, 番号 5, 10.06.1998, p. 681-684.

研究成果: ジャーナルへの寄稿記事

Shibuta, K. ; Mori, Masaki ; Haraguchi, M. ; Yoshikawa, K. ; Ueo, H. ; Akiyoshi, T. / Association between restriction fragment length polymorphism of the L- myc gene and susceptibility to gastric cancer. :: British Journal of Surgery. 1998 ; 巻 85, 番号 5. pp. 681-684.
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abstract = "Background: L-myc polymorphism has been documented to be a representative genetic trait which is related an individual's susceptibility to several cancers. However, there have been no reports concerning any significant association between susceptibility to gastric cancer and L-myc polymorphism. Methods: The distribution of L-myc polymorphism in 61 patients with gastric cancer was determined by polymerase chain reaction-based restriction fragment length polymorphism and compared with that of 107 healthy control subjects. Results: There was a significant difference in the distribution of both genotypes (P = 0.024) and allele frequencies (P = 0.026) between the two groups. The relative risk of gastric cancer for genotypes with the shorter (S) allele was 3.09 compared with the longer (L) allele homozygote. No significant correlation with clinicopathological features of the cancers except for prognosis was found. The patients with SS genotypes had a worse prognosis than those with LL or LS genotypes (P = 0.029). Conclusion: L-myc polymorphism may be significant in an individual's susceptibility to gastric cancer in Japan, and may be a useful marker for identifying patients at high risk of developing gastric cancer.",
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AU - Shibuta, K.

AU - Mori, Masaki

AU - Haraguchi, M.

AU - Yoshikawa, K.

AU - Ueo, H.

AU - Akiyoshi, T.

PY - 1998/6/10

Y1 - 1998/6/10

N2 - Background: L-myc polymorphism has been documented to be a representative genetic trait which is related an individual's susceptibility to several cancers. However, there have been no reports concerning any significant association between susceptibility to gastric cancer and L-myc polymorphism. Methods: The distribution of L-myc polymorphism in 61 patients with gastric cancer was determined by polymerase chain reaction-based restriction fragment length polymorphism and compared with that of 107 healthy control subjects. Results: There was a significant difference in the distribution of both genotypes (P = 0.024) and allele frequencies (P = 0.026) between the two groups. The relative risk of gastric cancer for genotypes with the shorter (S) allele was 3.09 compared with the longer (L) allele homozygote. No significant correlation with clinicopathological features of the cancers except for prognosis was found. The patients with SS genotypes had a worse prognosis than those with LL or LS genotypes (P = 0.029). Conclusion: L-myc polymorphism may be significant in an individual's susceptibility to gastric cancer in Japan, and may be a useful marker for identifying patients at high risk of developing gastric cancer.

AB - Background: L-myc polymorphism has been documented to be a representative genetic trait which is related an individual's susceptibility to several cancers. However, there have been no reports concerning any significant association between susceptibility to gastric cancer and L-myc polymorphism. Methods: The distribution of L-myc polymorphism in 61 patients with gastric cancer was determined by polymerase chain reaction-based restriction fragment length polymorphism and compared with that of 107 healthy control subjects. Results: There was a significant difference in the distribution of both genotypes (P = 0.024) and allele frequencies (P = 0.026) between the two groups. The relative risk of gastric cancer for genotypes with the shorter (S) allele was 3.09 compared with the longer (L) allele homozygote. No significant correlation with clinicopathological features of the cancers except for prognosis was found. The patients with SS genotypes had a worse prognosis than those with LL or LS genotypes (P = 0.029). Conclusion: L-myc polymorphism may be significant in an individual's susceptibility to gastric cancer in Japan, and may be a useful marker for identifying patients at high risk of developing gastric cancer.

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