TY - JOUR
T1 - Association between serum glycated albumin and risk of cardiovascular disease in a Japanese community
T2 - The Hisayama Study
AU - Mihara, Akane
AU - Ohara, Tomoyuki
AU - Hata, Jun
AU - Honda, Takanori
AU - Chen, Sanmei
AU - Sakata, Satoko
AU - Oishi, Emi
AU - Hirakawa, Yoichiro
AU - Nakao, Tomohiro
AU - Kitazono, Takanari
AU - Ninomiya, Toshiharu
PY - 2020/10
Y1 - 2020/10
N2 - Background and aims: We aimed to investigate the association of serum glycated albumin (GA) levels with the risk of cardiovascular disease (CVD) and its subtypes, including coronary heart disease (CHD) and stroke, in a general Japanese population. Methods: A total of 2965 Japanese community-dwellers aged ≥40 years were followed prospectively for a median of 10.2 years (2002–2012). Serum GA was measured by the enzymatic method and divided into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum GA levels on CVD risk. Results: During the follow-up, 213 subjects developed CVD; 95 had CHD, and 133 had stroke. The cumulative incidence of CVD, CHD, and stroke increased significantly with increasing serum GA levels (all p for trend <0.02). Compared with the lowest serum GA quartile (<13.6%), the multivariable-adjusted HRs (95% CI) of the highest quartile (≥15.7%) were 2.33 (1.46–3.68) for CVD, 2.23 (1.11–4.50) for CHD, and 2.47 (1.38–4.40) for stroke. In addition, a subgroup analysis showed that CVD risk increased significantly with increasing levels of serum GA in both subjects with and without diabetes mellitus. The increasing trend of CVD risk for higher serum GA levels was also observed in subjects with low hemoglobin A1c levels (hemoglobin A1c <5.46%). Conclusions: Our findings suggest that higher serum GA levels are significantly associated with the development of CVD and its subtypes, even among subjects without diabetes or those with normal hemoglobin A1c levels, in a general Japanese population.
AB - Background and aims: We aimed to investigate the association of serum glycated albumin (GA) levels with the risk of cardiovascular disease (CVD) and its subtypes, including coronary heart disease (CHD) and stroke, in a general Japanese population. Methods: A total of 2965 Japanese community-dwellers aged ≥40 years were followed prospectively for a median of 10.2 years (2002–2012). Serum GA was measured by the enzymatic method and divided into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum GA levels on CVD risk. Results: During the follow-up, 213 subjects developed CVD; 95 had CHD, and 133 had stroke. The cumulative incidence of CVD, CHD, and stroke increased significantly with increasing serum GA levels (all p for trend <0.02). Compared with the lowest serum GA quartile (<13.6%), the multivariable-adjusted HRs (95% CI) of the highest quartile (≥15.7%) were 2.33 (1.46–3.68) for CVD, 2.23 (1.11–4.50) for CHD, and 2.47 (1.38–4.40) for stroke. In addition, a subgroup analysis showed that CVD risk increased significantly with increasing levels of serum GA in both subjects with and without diabetes mellitus. The increasing trend of CVD risk for higher serum GA levels was also observed in subjects with low hemoglobin A1c levels (hemoglobin A1c <5.46%). Conclusions: Our findings suggest that higher serum GA levels are significantly associated with the development of CVD and its subtypes, even among subjects without diabetes or those with normal hemoglobin A1c levels, in a general Japanese population.
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U2 - 10.1016/j.atherosclerosis.2020.08.016
DO - 10.1016/j.atherosclerosis.2020.08.016
M3 - Article
C2 - 32942084
AN - SCOPUS:85090729201
VL - 311
SP - 52
EP - 59
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
ER -