Association between serum vitamin D and All-Cause and Cause-Specific death in a general Japanese population ― the hisayama study ―

研究成果: ジャーナルへの寄稿記事

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抄録

Background: Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations. Methods and Results: We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002-2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)2D levels (HR 1.54 [95% confidence interval, 1.18-2.01] for the lowest quartile, 1.31 [0.99-1.73] for the 2nd quartile, 0.94 [0.70-1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than in those with eGFR ≥60 mL/min/1.73 m2; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). Conclusions: The findings suggested that a lower serum 1,25(OH)2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.

元の言語英語
ページ(範囲)1315-1321
ページ数7
ジャーナルCirculation Journal
81
発行部数9
DOI
出版物ステータス出版済み - 1 1 2017

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Vitamin D
Cause of Death
Respiratory Tract Infections
Cardiovascular Infections
Serum
Glomerular Filtration Rate
Population
Independent Living
Confidence Intervals
Kidney
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

@article{b70eefeaed764a37aabf804409ff19e2,
title = "Association between serum vitamin D and All-Cause and Cause-Specific death in a general Japanese population ― the hisayama study ―",
abstract = "Background: Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations. Methods and Results: We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002-2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)2D levels (HR 1.54 [95{\%} confidence interval, 1.18-2.01] for the lowest quartile, 1.31 [0.99-1.73] for the 2nd quartile, 0.94 [0.70-1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than in those with eGFR ≥60 mL/min/1.73 m2; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). Conclusions: The findings suggested that a lower serum 1,25(OH)2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.",
author = "kaoru umehara and Naoko Mukai and Jun Hata and Yoichiro Hirakawa and Tomoyuki Ohara and Daigo Yoshida and Hiro Kishimoto and Takanari Kitazono and Sumio Hoka and Yutaka Kiyohara and Toshiharu Ninomiya",
year = "2017",
month = "1",
day = "1",
doi = "10.1253/circj.CJ-16-0954",
language = "English",
volume = "81",
pages = "1315--1321",
journal = "Circulation Journal",
issn = "1346-9843",
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TY - JOUR

T1 - Association between serum vitamin D and All-Cause and Cause-Specific death in a general Japanese population ― the hisayama study ―

AU - umehara, kaoru

AU - Mukai, Naoko

AU - Hata, Jun

AU - Hirakawa, Yoichiro

AU - Ohara, Tomoyuki

AU - Yoshida, Daigo

AU - Kishimoto, Hiro

AU - Kitazono, Takanari

AU - Hoka, Sumio

AU - Kiyohara, Yutaka

AU - Ninomiya, Toshiharu

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations. Methods and Results: We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002-2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)2D levels (HR 1.54 [95% confidence interval, 1.18-2.01] for the lowest quartile, 1.31 [0.99-1.73] for the 2nd quartile, 0.94 [0.70-1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than in those with eGFR ≥60 mL/min/1.73 m2; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). Conclusions: The findings suggested that a lower serum 1,25(OH)2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.

AB - Background: Few studies have investigated the association between serum vitamin D levels and mortality in general Asian populations. Methods and Results: We examined the association of serum 1,25-dihydroxyvitamin D (1,25(OH)2D) levels with the risk of all-cause and cause-specific death in an average 9.5-year follow-up study of 3,292 community-dwelling Japanese subjects aged ≥40 years (2002-2012). The multivariable-adjusted hazard ratio (HR) for all-cause death increased significantly with lower serum 1,25(OH)2D levels (HR 1.54 [95% confidence interval, 1.18-2.01] for the lowest quartile, 1.31 [0.99-1.73] for the 2nd quartile, 0.94 [0.70-1.25] for the 3rd quartile, 1.00 [Ref.] for highest quartile; P for trend <0.001). A similar association was observed for cardiovascular and respiratory infection death (both P for trend <0.01), but not for cancer death or death from other causes. In the stratified analysis, the association between lower serum 1,25(OH)2D levels and the risk of respiratory infection death was stronger in subjects with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than in those with eGFR ≥60 mL/min/1.73 m2; there was a significant heterogeneity in the association between eGFR levels (P for heterogeneity=0.04). Conclusions: The findings suggested that a lower serum 1,25(OH)2D level is a potential risk factor for all-cause death, especially cardiovascular and respiratory infection death, in the general Japanese population, and that lower serum 1,25(OH)2D levels greatly increase the risk of respiratory infection death in subjects with kidney dysfunction.

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U2 - 10.1253/circj.CJ-16-0954

DO - 10.1253/circj.CJ-16-0954

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