Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica

Wei Li, Motozumi Minohara, Hua Piao, Takuya Matsushita, Katsuhisa Masaki, Takeshi Matsuoka, Noriko Isobe, Jen Jen Su, Yasumasa Ohyagi, Jun-Ichi Kira

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

抄録

There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) and half of OSMS patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common in CMS patients than controls. To reveal the immune responses to the H. pylori neutrophil-activating protein (HP-NAP) in Japanese MS patients, according to anti-AQP4 antibody status, sera from 162 MS patients, 37 patients with other inflammatory neurological diseases (OIND), and 85 healthy subjects were assayed for anti-H. pylori antibodies, anti-HP-NAP antibodies, and myeloperoxidase (MPO) by enzyme immunoassays. H. pylori seropositivity rates were significantly higher in anti-AQP4 antibody-positive MS/NMO (AQP4 + /MS) patients (19/27, 70.4%) than anti-AQP4 antibody-negative CMS (AQP4 - /CMS) patients (22/83, 26.5%). Among H. pylori-infected individuals, the anti-HP-NAP antibody was significantly more common in AQP4 + /MS and AQP4 - /OSMS patients than healthy subjects (36.8%, 34.6% versus 2.8%). Among the AQP4 + /MS patients, a significant positive correlation between anti-HP-NAP antibody levels and the final Kurtzkes Expanded Disability Status Scale scores was found, and MPO levels were higher in anti-HP-NAP antibody-positive patients than anti-HP-NAP antibody-negative ones. Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients.

元の言語英語
ページ(範囲)1411-1421
ページ数11
ジャーナルMultiple Sclerosis
15
発行部数12
DOI
出版物ステータス出版済み - 12 1 2009

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Aquaporin 4
Neuromyelitis Optica
Autoimmunity
Multiple Sclerosis
Antibody Formation
Antibodies
Helicobacter pylori
Peroxidase
Healthy Volunteers
Helicobacter pylori neutrophil-activating protein A
Helicobacter Infections
Immunoenzyme Techniques
Anti-Idiotypic Antibodies

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

これを引用

Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica. / Li, Wei; Minohara, Motozumi; Piao, Hua; Matsushita, Takuya; Masaki, Katsuhisa; Matsuoka, Takeshi; Isobe, Noriko; Su, Jen Jen; Ohyagi, Yasumasa; Kira, Jun-Ichi.

:: Multiple Sclerosis, 巻 15, 番号 12, 01.12.2009, p. 1411-1421.

研究成果: ジャーナルへの寄稿記事

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title = "Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica",
abstract = "There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) and half of OSMS patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common in CMS patients than controls. To reveal the immune responses to the H. pylori neutrophil-activating protein (HP-NAP) in Japanese MS patients, according to anti-AQP4 antibody status, sera from 162 MS patients, 37 patients with other inflammatory neurological diseases (OIND), and 85 healthy subjects were assayed for anti-H. pylori antibodies, anti-HP-NAP antibodies, and myeloperoxidase (MPO) by enzyme immunoassays. H. pylori seropositivity rates were significantly higher in anti-AQP4 antibody-positive MS/NMO (AQP4 + /MS) patients (19/27, 70.4{\%}) than anti-AQP4 antibody-negative CMS (AQP4 - /CMS) patients (22/83, 26.5{\%}). Among H. pylori-infected individuals, the anti-HP-NAP antibody was significantly more common in AQP4 + /MS and AQP4 - /OSMS patients than healthy subjects (36.8{\%}, 34.6{\%} versus 2.8{\%}). Among the AQP4 + /MS patients, a significant positive correlation between anti-HP-NAP antibody levels and the final Kurtzkes Expanded Disability Status Scale scores was found, and MPO levels were higher in anti-HP-NAP antibody-positive patients than anti-HP-NAP antibody-negative ones. Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients.",
author = "Wei Li and Motozumi Minohara and Hua Piao and Takuya Matsushita and Katsuhisa Masaki and Takeshi Matsuoka and Noriko Isobe and Su, {Jen Jen} and Yasumasa Ohyagi and Jun-Ichi Kira",
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AU - Li, Wei

AU - Minohara, Motozumi

AU - Piao, Hua

AU - Matsushita, Takuya

AU - Masaki, Katsuhisa

AU - Matsuoka, Takeshi

AU - Isobe, Noriko

AU - Su, Jen Jen

AU - Ohyagi, Yasumasa

AU - Kira, Jun-Ichi

PY - 2009/12/1

Y1 - 2009/12/1

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AB - There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) and half of OSMS patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody. We reported that Helicobacter pylori (H. pylori) infection was significantly less common in CMS patients than controls. To reveal the immune responses to the H. pylori neutrophil-activating protein (HP-NAP) in Japanese MS patients, according to anti-AQP4 antibody status, sera from 162 MS patients, 37 patients with other inflammatory neurological diseases (OIND), and 85 healthy subjects were assayed for anti-H. pylori antibodies, anti-HP-NAP antibodies, and myeloperoxidase (MPO) by enzyme immunoassays. H. pylori seropositivity rates were significantly higher in anti-AQP4 antibody-positive MS/NMO (AQP4 + /MS) patients (19/27, 70.4%) than anti-AQP4 antibody-negative CMS (AQP4 - /CMS) patients (22/83, 26.5%). Among H. pylori-infected individuals, the anti-HP-NAP antibody was significantly more common in AQP4 + /MS and AQP4 - /OSMS patients than healthy subjects (36.8%, 34.6% versus 2.8%). Among the AQP4 + /MS patients, a significant positive correlation between anti-HP-NAP antibody levels and the final Kurtzkes Expanded Disability Status Scale scores was found, and MPO levels were higher in anti-HP-NAP antibody-positive patients than anti-HP-NAP antibody-negative ones. Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients.

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