Association of genetic risk score and chronic kidney disease in a Japanese population

Ryosuke Fujii, Asahi Hishida, Masahiro Nakatochi, Norihiro Furusyo, Murata Masayuki, Keitaro Tanaka, Chisato Shimanoe, Sadao Suzuki, Miki Watanabe, Nagato Kuriyama, Teruhide Koyama, Toshiro Takezaki, Ippei Shimoshikiryo, Kokichi Arisawa, Sakurako Katsuura-Kamano, Naoyuki Takashima, Tanvir C. Turin, Kiyonori Kuriki, Kaori Endoh, Haruo Mikami & 8 others Yohko Nakamura, Isao Oze, Hidemi Ito, Michiaki Kubo, Yukihide Momozawa, Takaaki Kondo, Mariko Naito, Kenji Wakai

研究成果: ジャーナルへの寄稿記事

抄録

Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m 2 was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042–1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.

元の言語英語
ページ(範囲)670-673
ページ数4
ジャーナルNephrology
24
発行部数6
DOI
出版物ステータス出版済み - 6 1 2019

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Chronic Renal Insufficiency
Population
Genetic Models
Japan
Risk Adjustment
Genome-Wide Association Study
Disease Susceptibility
Type 2 Diabetes Mellitus
Single Nucleotide Polymorphism
Cohort Studies
Public Health
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Hypertension

All Science Journal Classification (ASJC) codes

  • Nephrology

これを引用

Fujii, R., Hishida, A., Nakatochi, M., Furusyo, N., Masayuki, M., Tanaka, K., ... Wakai, K. (2019). Association of genetic risk score and chronic kidney disease in a Japanese population. Nephrology, 24(6), 670-673. https://doi.org/10.1111/nep.13479

Association of genetic risk score and chronic kidney disease in a Japanese population. / Fujii, Ryosuke; Hishida, Asahi; Nakatochi, Masahiro; Furusyo, Norihiro; Masayuki, Murata; Tanaka, Keitaro; Shimanoe, Chisato; Suzuki, Sadao; Watanabe, Miki; Kuriyama, Nagato; Koyama, Teruhide; Takezaki, Toshiro; Shimoshikiryo, Ippei; Arisawa, Kokichi; Katsuura-Kamano, Sakurako; Takashima, Naoyuki; Turin, Tanvir C.; Kuriki, Kiyonori; Endoh, Kaori; Mikami, Haruo; Nakamura, Yohko; Oze, Isao; Ito, Hidemi; Kubo, Michiaki; Momozawa, Yukihide; Kondo, Takaaki; Naito, Mariko; Wakai, Kenji.

:: Nephrology, 巻 24, 番号 6, 01.06.2019, p. 670-673.

研究成果: ジャーナルへの寄稿記事

Fujii, R, Hishida, A, Nakatochi, M, Furusyo, N, Masayuki, M, Tanaka, K, Shimanoe, C, Suzuki, S, Watanabe, M, Kuriyama, N, Koyama, T, Takezaki, T, Shimoshikiryo, I, Arisawa, K, Katsuura-Kamano, S, Takashima, N, Turin, TC, Kuriki, K, Endoh, K, Mikami, H, Nakamura, Y, Oze, I, Ito, H, Kubo, M, Momozawa, Y, Kondo, T, Naito, M & Wakai, K 2019, 'Association of genetic risk score and chronic kidney disease in a Japanese population', Nephrology, 巻. 24, 番号 6, pp. 670-673. https://doi.org/10.1111/nep.13479
Fujii, Ryosuke ; Hishida, Asahi ; Nakatochi, Masahiro ; Furusyo, Norihiro ; Masayuki, Murata ; Tanaka, Keitaro ; Shimanoe, Chisato ; Suzuki, Sadao ; Watanabe, Miki ; Kuriyama, Nagato ; Koyama, Teruhide ; Takezaki, Toshiro ; Shimoshikiryo, Ippei ; Arisawa, Kokichi ; Katsuura-Kamano, Sakurako ; Takashima, Naoyuki ; Turin, Tanvir C. ; Kuriki, Kiyonori ; Endoh, Kaori ; Mikami, Haruo ; Nakamura, Yohko ; Oze, Isao ; Ito, Hidemi ; Kubo, Michiaki ; Momozawa, Yukihide ; Kondo, Takaaki ; Naito, Mariko ; Wakai, Kenji. / Association of genetic risk score and chronic kidney disease in a Japanese population. :: Nephrology. 2019 ; 巻 24, 番号 6. pp. 670-673.
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abstract = "Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m 2 was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3{\%}, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95{\%} confidence interval: 1.042–1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.",
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T1 - Association of genetic risk score and chronic kidney disease in a Japanese population

AU - Fujii, Ryosuke

AU - Hishida, Asahi

AU - Nakatochi, Masahiro

AU - Furusyo, Norihiro

AU - Masayuki, Murata

AU - Tanaka, Keitaro

AU - Shimanoe, Chisato

AU - Suzuki, Sadao

AU - Watanabe, Miki

AU - Kuriyama, Nagato

AU - Koyama, Teruhide

AU - Takezaki, Toshiro

AU - Shimoshikiryo, Ippei

AU - Arisawa, Kokichi

AU - Katsuura-Kamano, Sakurako

AU - Takashima, Naoyuki

AU - Turin, Tanvir C.

AU - Kuriki, Kiyonori

AU - Endoh, Kaori

AU - Mikami, Haruo

AU - Nakamura, Yohko

AU - Oze, Isao

AU - Ito, Hidemi

AU - Kubo, Michiaki

AU - Momozawa, Yukihide

AU - Kondo, Takaaki

AU - Naito, Mariko

AU - Wakai, Kenji

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Chronic kidney disease (CKD) is a public health problem worldwide including Japan. Recent genome-wide association studies have discovered CKD susceptibility variants. We developed a genetic risk score (GRS) based on CKD-associated variants and assessed a possibility that the GRS can improve the discrimination capability for the prevalence of CKD in a Japanese population. The present study consists of 11 283 participants randomly selected from 12 Japan Multi-Institutional Collaborative Cohort Study sites. Individual GRS was constructed combining 18 single-nucleotide polymorphisms identified in a Japanese population. Participants with eGFR <60 mL/min per 1.73 m 2 was defined as case (stage 3 CKD or higher) in this study. Logistic regression analysis was used to examine the association between the GRS and CKD risk with adjustment for sex, age, hypertension and type 2 diabetes mellitus. The frequency of individuals with CKD was 8.3%, which was relatively low compared with those previously reported in a Japanese population. The odds ratio of having CKD was 1.120 (95% confidence interval: 1.042–1.203) per 10 GRS increment in the fully adjusted model (P = 0.002). The C-statistic was significantly increased in the model with the GRS, comparing with the model without the GRS (0.720 vs 0.719, P difference = 0.008). Increment of the GRS was associated with increased risk of CKD. Additionally, the GRS significantly improved the discriminatory ability of CKD prevalence in a Japanese population; however, the improvement of discriminatory ability brought about by the GRS seemed to be small compared with that of non-genetic CKD risk factors.

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