Association of genetically determined aldehyde dehydrogenase 2 activity with diabetic complications in relation to alcohol consumption in Japanese patients with type 2 diabetes mellitus: The fukuoka diabetes registry

Yasuhiro Idewaki, Masanori Iwase, Hiroki Fujii, Toshiaki Ohkuma, Hitoshi Ide, Shinako Kaizu, Tamaki Jodai, Yohei Kikuchi, Atsushi Hirano, Udai Nakamura, Michiaki Kubo, Takanari Kitazono

研究成果: Contribution to journalArticle査読

14 被引用数 (Scopus)

抄録

Aldehyde dehydrogenase 2 (ALDH2) detoxifies aldehyde produced during ethanol metabolism and oxidative stress. A genetic defect in this enzyme is common in East Asians and determines alcohol consumption behaviors. We investigated the impact of genetically determined ALDH2 activity on diabetic microvascular and macrovascular complications in relation to drinking habits in Japanese patients with type 2 diabetes mellitus. An ALDH2 singlenucleotide polymorphism (rs671) was genotyped in 4,400 patients. Additionally, the relationship of clinical characteristics with ALDH2 activity (ALDH2 1/1 active enzyme activity vs. 1/2 or 2/2 inactive enzyme activity) and drinking habits (lifetime abstainers vs. former or current drinkers) was investigated cross-sectionally (n = 691 in 1/1 abstainers, n = 1,315 in abstainers with 2, n = 1,711 in 1/1 drinkers, n = 683 in drinkers with 2). The multiple logistic regression analysis for diabetic complications was adjusted for age, sex, current smoking habits, leisure-time physical activity, depressive symptoms, diabetes duration, body mass index, hemoglobin A1c, insulin use, high-density lipoprotein cholesterol, systolic blood pressure and renin-angiotensin system inhibitors use. Albuminuria prevalence was significantly lower in the drinkers with 2 than that of other groups (odds ratio [95% confidence interval (CI)]: 1/1 abstainers as the referent, 0.94 [0.76-1.16] in abstainers with 2, 1.00 [0.80-1.26] in 1/1 drinkers, 0.71 [0.54-0.93] in drinkers with 2). Retinal photocoagulation prevalence was also lower in drinkers with ALDH2 2 than that of other groups. In contrast, myocardial infarction was significantly increased in ALDH2 2 carriers compared with that in ALDH2 1/1 abstainers (odds ratio [95% CI]: 1/1 abstainers as the referent, 2.63 [1.28-6.13] in abstainers with 2, 1.89 [0.89-4.51] in 1/1 drinkers, 2.35 [1.06-5.79] in drinkers with 2). In summary, patients with type 2 diabetes and ALDH2 2 displayed a lower microvascular complication prevalence associated with alcohol consumption but a higher macrovascular complication prevalence irrespective of alcohol consumption.

本文言語英語
論文番号e0143288
ジャーナルPloS one
10
11
DOI
出版ステータス出版済み - 11 1 2015

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 農業および生物科学(全般)
  • 一般

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