Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection

a Japanese cross-sectional study

Hiroaki Ikezaki, Norihiro Furusyo, Satoshi Hiramine, Kazuya Ura, Fujiko Mitsumoto-Kaseida, Koji Takayama, Motohiro Shimizu, Kazuhiro Toyoda, Eiichi Ogawa, Mosaburo Kainuma, Murata Masayuki, Jun Hayashi

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Hepatitis C virus (HCV) infection is a serious global health problem. Previous studies have suggested that the interleukin 28B (IL28B) rs8099917 genotype is related to spontaneous clearance of HCV in Caucasian populations. Our objective was to investigate the association of the IL28B rs8099917 genotype with spontaneous clearance of HCV by community-dwelling Japanese. A cross-sectional community-based population study of 993 Japanese residents was conducted. Based on anti-HCV antibody and HCV RNA levels, 50 subjects were assigned to the spontaneous-clearance group, 155 to the chronic-infection group, and 788 to the control group. Logistic regression analysis was done to examine the roles of the IL28B rs8099917 genotype and sex. To analyze the interactions between these factors, an “IL28B rs809991 genotype × sex” interaction term was included in the multivariate analysis. Significantly more subjects in the spontaneous-clearance group than in the chronic-infection group had the favorable IL28B rs8099917 genotype and were female. Multivariate logistic regression analysis extracted the favorable IL28B rs8099917 TT genotype (odds ratio [OR] 9.39; 95 % confidence interval [CI], 2.16–40.83, P = 0.003) and female sex (OR, 2.27; 95 % CI, 1.16–4.45, P = 0.017) as factors contributing to the spontaneous clearance of HCV. No significant interaction was found between the IL28B rs8099917 genotype and sex (P for interaction = 0.428). Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population.

元の言語英語
ページ(範囲)641-648
ページ数8
ジャーナルArchives of Virology
161
発行部数3
DOI
出版物ステータス出版済み - 3 1 2016

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Interleukins
Virus Diseases
Hepacivirus
Cross-Sectional Studies
Genotype
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Population
Independent Living
Hepatitis C Antibodies
Sex Ratio
Infection
Multivariate Analysis
RNA
Control Groups

All Science Journal Classification (ASJC) codes

  • Virology

これを引用

Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection : a Japanese cross-sectional study. / Ikezaki, Hiroaki; Furusyo, Norihiro; Hiramine, Satoshi; Ura, Kazuya; Mitsumoto-Kaseida, Fujiko; Takayama, Koji; Shimizu, Motohiro; Toyoda, Kazuhiro; Ogawa, Eiichi; Kainuma, Mosaburo; Masayuki, Murata; Hayashi, Jun.

:: Archives of Virology, 巻 161, 番号 3, 01.03.2016, p. 641-648.

研究成果: ジャーナルへの寄稿記事

Ikezaki, Hiroaki ; Furusyo, Norihiro ; Hiramine, Satoshi ; Ura, Kazuya ; Mitsumoto-Kaseida, Fujiko ; Takayama, Koji ; Shimizu, Motohiro ; Toyoda, Kazuhiro ; Ogawa, Eiichi ; Kainuma, Mosaburo ; Masayuki, Murata ; Hayashi, Jun. / Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection : a Japanese cross-sectional study. :: Archives of Virology. 2016 ; 巻 161, 番号 3. pp. 641-648.
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abstract = "Hepatitis C virus (HCV) infection is a serious global health problem. Previous studies have suggested that the interleukin 28B (IL28B) rs8099917 genotype is related to spontaneous clearance of HCV in Caucasian populations. Our objective was to investigate the association of the IL28B rs8099917 genotype with spontaneous clearance of HCV by community-dwelling Japanese. A cross-sectional community-based population study of 993 Japanese residents was conducted. Based on anti-HCV antibody and HCV RNA levels, 50 subjects were assigned to the spontaneous-clearance group, 155 to the chronic-infection group, and 788 to the control group. Logistic regression analysis was done to examine the roles of the IL28B rs8099917 genotype and sex. To analyze the interactions between these factors, an “IL28B rs809991 genotype × sex” interaction term was included in the multivariate analysis. Significantly more subjects in the spontaneous-clearance group than in the chronic-infection group had the favorable IL28B rs8099917 genotype and were female. Multivariate logistic regression analysis extracted the favorable IL28B rs8099917 TT genotype (odds ratio [OR] 9.39; 95 {\%} confidence interval [CI], 2.16–40.83, P = 0.003) and female sex (OR, 2.27; 95 {\%} CI, 1.16–4.45, P = 0.017) as factors contributing to the spontaneous clearance of HCV. No significant interaction was found between the IL28B rs8099917 genotype and sex (P for interaction = 0.428). Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population.",
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T1 - Association of IL28B rs8099917 genotype and female sex with spontaneous clearance of hepatitis C virus infection

T2 - a Japanese cross-sectional study

AU - Ikezaki, Hiroaki

AU - Furusyo, Norihiro

AU - Hiramine, Satoshi

AU - Ura, Kazuya

AU - Mitsumoto-Kaseida, Fujiko

AU - Takayama, Koji

AU - Shimizu, Motohiro

AU - Toyoda, Kazuhiro

AU - Ogawa, Eiichi

AU - Kainuma, Mosaburo

AU - Masayuki, Murata

AU - Hayashi, Jun

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Hepatitis C virus (HCV) infection is a serious global health problem. Previous studies have suggested that the interleukin 28B (IL28B) rs8099917 genotype is related to spontaneous clearance of HCV in Caucasian populations. Our objective was to investigate the association of the IL28B rs8099917 genotype with spontaneous clearance of HCV by community-dwelling Japanese. A cross-sectional community-based population study of 993 Japanese residents was conducted. Based on anti-HCV antibody and HCV RNA levels, 50 subjects were assigned to the spontaneous-clearance group, 155 to the chronic-infection group, and 788 to the control group. Logistic regression analysis was done to examine the roles of the IL28B rs8099917 genotype and sex. To analyze the interactions between these factors, an “IL28B rs809991 genotype × sex” interaction term was included in the multivariate analysis. Significantly more subjects in the spontaneous-clearance group than in the chronic-infection group had the favorable IL28B rs8099917 genotype and were female. Multivariate logistic regression analysis extracted the favorable IL28B rs8099917 TT genotype (odds ratio [OR] 9.39; 95 % confidence interval [CI], 2.16–40.83, P = 0.003) and female sex (OR, 2.27; 95 % CI, 1.16–4.45, P = 0.017) as factors contributing to the spontaneous clearance of HCV. No significant interaction was found between the IL28B rs8099917 genotype and sex (P for interaction = 0.428). Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population.

AB - Hepatitis C virus (HCV) infection is a serious global health problem. Previous studies have suggested that the interleukin 28B (IL28B) rs8099917 genotype is related to spontaneous clearance of HCV in Caucasian populations. Our objective was to investigate the association of the IL28B rs8099917 genotype with spontaneous clearance of HCV by community-dwelling Japanese. A cross-sectional community-based population study of 993 Japanese residents was conducted. Based on anti-HCV antibody and HCV RNA levels, 50 subjects were assigned to the spontaneous-clearance group, 155 to the chronic-infection group, and 788 to the control group. Logistic regression analysis was done to examine the roles of the IL28B rs8099917 genotype and sex. To analyze the interactions between these factors, an “IL28B rs809991 genotype × sex” interaction term was included in the multivariate analysis. Significantly more subjects in the spontaneous-clearance group than in the chronic-infection group had the favorable IL28B rs8099917 genotype and were female. Multivariate logistic regression analysis extracted the favorable IL28B rs8099917 TT genotype (odds ratio [OR] 9.39; 95 % confidence interval [CI], 2.16–40.83, P = 0.003) and female sex (OR, 2.27; 95 % CI, 1.16–4.45, P = 0.017) as factors contributing to the spontaneous clearance of HCV. No significant interaction was found between the IL28B rs8099917 genotype and sex (P for interaction = 0.428). Both the favorable IL28B rs8099917 genotype and female sex were associated with the spontaneous clearance of HCV in this Japanese population.

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DO - 10.1007/s00705-015-2703-9

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