Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation

Hideya Kamei, Satohiro Masuda, Masatoshi Ishigami, Taro Nakamura, Yasuhiro Fujimoto, Yasutsugu Takada, Nobuyuki Hamajima

研究成果: ジャーナルへの寄稿記事

抄録

Background: Little is known as to whether the interleukin4 (IL4) gene polymorphisms in recipients or donors affect the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Therefore, we determined the effect of IL4 T-33C polymorphisms in recipients and donors on ACR in a large cohort of patients that underwent LDLT. Methods: We examined 155 LDLT cases treated at Nagoya University or Kyoto University, Japan, between 2004 and 2009. IL4 T-33C polymorphisms were analyzed in recipients and donors. Results: Forty-seven recipients (30.3%) developed early ACR. The genotype frequency of IL4 T-33C in the recipients was associated with ACR incidence (P = 0.008, P < 0.0125 considered significant). Patients with the IL4-33C carrier genotype (C/C or C/T) were significantly associated with a higher incidence of ACR relative to those with the T/T genotype (OR = 3.27, 95% CI: 1.56-6.88, P = 0.002). The genotype frequencies of IL4 T-33C in the donors were not associated with rejection incidence. In addition, there was no significant effect of IL4 T-33C genotype combinations on ACR incidence in donors and recipients. Conclusions: Genotyping of IL4 T-33C in recipients might be useful to stratify the liver transplant recipients according to their risk of ACR.

元の言語英語
ページ(範囲)179-185
ページ数7
ジャーナルClinics and Research in Hepatology and Gastroenterology
40
発行部数2
DOI
出版物ステータス出版済み - 4 1 2016
外部発表Yes

Fingerprint

Living Donors
Liver Transplantation
Genotype
Tissue Donors
Incidence
Genes
Japan
Liver

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation. / Kamei, Hideya; Masuda, Satohiro; Ishigami, Masatoshi; Nakamura, Taro; Fujimoto, Yasuhiro; Takada, Yasutsugu; Hamajima, Nobuyuki.

:: Clinics and Research in Hepatology and Gastroenterology, 巻 40, 番号 2, 01.04.2016, p. 179-185.

研究成果: ジャーナルへの寄稿記事

Kamei, Hideya ; Masuda, Satohiro ; Ishigami, Masatoshi ; Nakamura, Taro ; Fujimoto, Yasuhiro ; Takada, Yasutsugu ; Hamajima, Nobuyuki. / Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation. :: Clinics and Research in Hepatology and Gastroenterology. 2016 ; 巻 40, 番号 2. pp. 179-185.
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abstract = "Background: Little is known as to whether the interleukin4 (IL4) gene polymorphisms in recipients or donors affect the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Therefore, we determined the effect of IL4 T-33C polymorphisms in recipients and donors on ACR in a large cohort of patients that underwent LDLT. Methods: We examined 155 LDLT cases treated at Nagoya University or Kyoto University, Japan, between 2004 and 2009. IL4 T-33C polymorphisms were analyzed in recipients and donors. Results: Forty-seven recipients (30.3{\%}) developed early ACR. The genotype frequency of IL4 T-33C in the recipients was associated with ACR incidence (P = 0.008, P < 0.0125 considered significant). Patients with the IL4-33C carrier genotype (C/C or C/T) were significantly associated with a higher incidence of ACR relative to those with the T/T genotype (OR = 3.27, 95{\%} CI: 1.56-6.88, P = 0.002). The genotype frequencies of IL4 T-33C in the donors were not associated with rejection incidence. In addition, there was no significant effect of IL4 T-33C genotype combinations on ACR incidence in donors and recipients. Conclusions: Genotyping of IL4 T-33C in recipients might be useful to stratify the liver transplant recipients according to their risk of ACR.",
author = "Hideya Kamei and Satohiro Masuda and Masatoshi Ishigami and Taro Nakamura and Yasuhiro Fujimoto and Yasutsugu Takada and Nobuyuki Hamajima",
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T1 - Association of interleukin4 gene polymorphisms of recipients and donors with acute rejection following living donor liver transplantation

AU - Kamei, Hideya

AU - Masuda, Satohiro

AU - Ishigami, Masatoshi

AU - Nakamura, Taro

AU - Fujimoto, Yasuhiro

AU - Takada, Yasutsugu

AU - Hamajima, Nobuyuki

PY - 2016/4/1

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N2 - Background: Little is known as to whether the interleukin4 (IL4) gene polymorphisms in recipients or donors affect the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Therefore, we determined the effect of IL4 T-33C polymorphisms in recipients and donors on ACR in a large cohort of patients that underwent LDLT. Methods: We examined 155 LDLT cases treated at Nagoya University or Kyoto University, Japan, between 2004 and 2009. IL4 T-33C polymorphisms were analyzed in recipients and donors. Results: Forty-seven recipients (30.3%) developed early ACR. The genotype frequency of IL4 T-33C in the recipients was associated with ACR incidence (P = 0.008, P < 0.0125 considered significant). Patients with the IL4-33C carrier genotype (C/C or C/T) were significantly associated with a higher incidence of ACR relative to those with the T/T genotype (OR = 3.27, 95% CI: 1.56-6.88, P = 0.002). The genotype frequencies of IL4 T-33C in the donors were not associated with rejection incidence. In addition, there was no significant effect of IL4 T-33C genotype combinations on ACR incidence in donors and recipients. Conclusions: Genotyping of IL4 T-33C in recipients might be useful to stratify the liver transplant recipients according to their risk of ACR.

AB - Background: Little is known as to whether the interleukin4 (IL4) gene polymorphisms in recipients or donors affect the incidence of acute cellular rejection (ACR) following living donor liver transplantation (LDLT). Therefore, we determined the effect of IL4 T-33C polymorphisms in recipients and donors on ACR in a large cohort of patients that underwent LDLT. Methods: We examined 155 LDLT cases treated at Nagoya University or Kyoto University, Japan, between 2004 and 2009. IL4 T-33C polymorphisms were analyzed in recipients and donors. Results: Forty-seven recipients (30.3%) developed early ACR. The genotype frequency of IL4 T-33C in the recipients was associated with ACR incidence (P = 0.008, P < 0.0125 considered significant). Patients with the IL4-33C carrier genotype (C/C or C/T) were significantly associated with a higher incidence of ACR relative to those with the T/T genotype (OR = 3.27, 95% CI: 1.56-6.88, P = 0.002). The genotype frequencies of IL4 T-33C in the donors were not associated with rejection incidence. In addition, there was no significant effect of IL4 T-33C genotype combinations on ACR incidence in donors and recipients. Conclusions: Genotyping of IL4 T-33C in recipients might be useful to stratify the liver transplant recipients according to their risk of ACR.

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