Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections

yasutaka kimoto, Takahiko Horiuchi, Hiroshi Tsukamoto, Chikako Kiyohara, Hiroki Mitoma, Ayumi Uchino, Isao Furugo, Seiji Yoshizawa, Akira Ueda, Shinichi Harashima, Takuya Sawabe, Tomoko Tahira, Kenshi Hayashi, Shigeru Yoshizawa, Terufumi Shimoda, Koichi Akashi, Mine Harada

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

抄録

Objective. Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections. Methods. Presence or absence of all 14 KIR genes was studied for association with SLE by case-control studies. A total of 417 SLE cases, 72 RA cases and 256 controls, all of Japanese descent, were enrolled. Results. The carrier frequency of KIR2DL5 was significantly decreased in SLE patients compared with healthy controls [39.3 vs 50.4%; odds ratio (OR) = 0.64; 95% CI 0.36, 0.92; P = 0.005). When the prevalence of severe infections was analysed in 184 SLE patients, whose medical records were available, KIR2DL5 carriers were at an increased risk of overall infection and viral infection (crude OR = 2.66; 95% CI 1.43, 4.92; P = 0.017 and crude OR = 2.31; 95% CI 1.15, 4.62; P = 0.017, respectively). After adjusting for methylprednisolone pulse and/or cyclophosphamide pulse therapy, KIR2DL5 carriers were at significantly greater risk of infectious events overall (adjusted OR = 2.45; 95% CI 1.24, 4.81; P = 0.0095). However, KIR2DL5 carriers were marginally associated with an increased risk of viral infectious events (adjusted OR = 2.03; 95% CI 0.94, 4.41; P = 0.0718). Conclusion. KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. Our data suggest a further role of KIRs in the pathogenesis of autoimmune diseases and infection.

元の言語英語
記事番号keq050
ページ(範囲)1346-1353
ページ数8
ジャーナルRheumatology
49
発行部数7
DOI
出版物ステータス出版済み - 4 5 2010

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KIR2DL5 Receptor
Systemic Lupus Erythematosus
Odds Ratio
KIR Receptors
Infection
Methylprednisolone
Virus Diseases
Cyclophosphamide
Genes
Autoimmune Diseases
Medical Records
Case-Control Studies

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Pharmacology (medical)

これを引用

Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections. / kimoto, yasutaka; Horiuchi, Takahiko; Tsukamoto, Hiroshi; Kiyohara, Chikako; Mitoma, Hiroki; Uchino, Ayumi; Furugo, Isao; Yoshizawa, Seiji; Ueda, Akira; Harashima, Shinichi; Sawabe, Takuya; Tahira, Tomoko; Hayashi, Kenshi; Yoshizawa, Shigeru; Shimoda, Terufumi; Akashi, Koichi; Harada, Mine.

:: Rheumatology, 巻 49, 番号 7, keq050, 05.04.2010, p. 1346-1353.

研究成果: ジャーナルへの寄稿記事

kimoto, Y, Horiuchi, T, Tsukamoto, H, Kiyohara, C, Mitoma, H, Uchino, A, Furugo, I, Yoshizawa, S, Ueda, A, Harashima, S, Sawabe, T, Tahira, T, Hayashi, K, Yoshizawa, S, Shimoda, T, Akashi, K & Harada, M 2010, 'Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections', Rheumatology, 巻. 49, 番号 7, keq050, pp. 1346-1353. https://doi.org/10.1093/rheumatology/keq050
kimoto, yasutaka ; Horiuchi, Takahiko ; Tsukamoto, Hiroshi ; Kiyohara, Chikako ; Mitoma, Hiroki ; Uchino, Ayumi ; Furugo, Isao ; Yoshizawa, Seiji ; Ueda, Akira ; Harashima, Shinichi ; Sawabe, Takuya ; Tahira, Tomoko ; Hayashi, Kenshi ; Yoshizawa, Shigeru ; Shimoda, Terufumi ; Akashi, Koichi ; Harada, Mine. / Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections. :: Rheumatology. 2010 ; 巻 49, 番号 7. pp. 1346-1353.
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abstract = "Objective. Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections. Methods. Presence or absence of all 14 KIR genes was studied for association with SLE by case-control studies. A total of 417 SLE cases, 72 RA cases and 256 controls, all of Japanese descent, were enrolled. Results. The carrier frequency of KIR2DL5 was significantly decreased in SLE patients compared with healthy controls [39.3 vs 50.4{\%}; odds ratio (OR) = 0.64; 95{\%} CI 0.36, 0.92; P = 0.005). When the prevalence of severe infections was analysed in 184 SLE patients, whose medical records were available, KIR2DL5 carriers were at an increased risk of overall infection and viral infection (crude OR = 2.66; 95{\%} CI 1.43, 4.92; P = 0.017 and crude OR = 2.31; 95{\%} CI 1.15, 4.62; P = 0.017, respectively). After adjusting for methylprednisolone pulse and/or cyclophosphamide pulse therapy, KIR2DL5 carriers were at significantly greater risk of infectious events overall (adjusted OR = 2.45; 95{\%} CI 1.24, 4.81; P = 0.0095). However, KIR2DL5 carriers were marginally associated with an increased risk of viral infectious events (adjusted OR = 2.03; 95{\%} CI 0.94, 4.41; P = 0.0718). Conclusion. KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. Our data suggest a further role of KIRs in the pathogenesis of autoimmune diseases and infection.",
author = "yasutaka kimoto and Takahiko Horiuchi and Hiroshi Tsukamoto and Chikako Kiyohara and Hiroki Mitoma and Ayumi Uchino and Isao Furugo and Seiji Yoshizawa and Akira Ueda and Shinichi Harashima and Takuya Sawabe and Tomoko Tahira and Kenshi Hayashi and Shigeru Yoshizawa and Terufumi Shimoda and Koichi Akashi and Mine Harada",
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T1 - Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections

AU - kimoto, yasutaka

AU - Horiuchi, Takahiko

AU - Tsukamoto, Hiroshi

AU - Kiyohara, Chikako

AU - Mitoma, Hiroki

AU - Uchino, Ayumi

AU - Furugo, Isao

AU - Yoshizawa, Seiji

AU - Ueda, Akira

AU - Harashima, Shinichi

AU - Sawabe, Takuya

AU - Tahira, Tomoko

AU - Hayashi, Kenshi

AU - Yoshizawa, Shigeru

AU - Shimoda, Terufumi

AU - Akashi, Koichi

AU - Harada, Mine

PY - 2010/4/5

Y1 - 2010/4/5

N2 - Objective. Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections. Methods. Presence or absence of all 14 KIR genes was studied for association with SLE by case-control studies. A total of 417 SLE cases, 72 RA cases and 256 controls, all of Japanese descent, were enrolled. Results. The carrier frequency of KIR2DL5 was significantly decreased in SLE patients compared with healthy controls [39.3 vs 50.4%; odds ratio (OR) = 0.64; 95% CI 0.36, 0.92; P = 0.005). When the prevalence of severe infections was analysed in 184 SLE patients, whose medical records were available, KIR2DL5 carriers were at an increased risk of overall infection and viral infection (crude OR = 2.66; 95% CI 1.43, 4.92; P = 0.017 and crude OR = 2.31; 95% CI 1.15, 4.62; P = 0.017, respectively). After adjusting for methylprednisolone pulse and/or cyclophosphamide pulse therapy, KIR2DL5 carriers were at significantly greater risk of infectious events overall (adjusted OR = 2.45; 95% CI 1.24, 4.81; P = 0.0095). However, KIR2DL5 carriers were marginally associated with an increased risk of viral infectious events (adjusted OR = 2.03; 95% CI 0.94, 4.41; P = 0.0718). Conclusion. KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. Our data suggest a further role of KIRs in the pathogenesis of autoimmune diseases and infection.

AB - Objective. Identification of the association of killer cell immunoglobulin-like receptor (KIR) genes with SLE and accompanying infections. Methods. Presence or absence of all 14 KIR genes was studied for association with SLE by case-control studies. A total of 417 SLE cases, 72 RA cases and 256 controls, all of Japanese descent, were enrolled. Results. The carrier frequency of KIR2DL5 was significantly decreased in SLE patients compared with healthy controls [39.3 vs 50.4%; odds ratio (OR) = 0.64; 95% CI 0.36, 0.92; P = 0.005). When the prevalence of severe infections was analysed in 184 SLE patients, whose medical records were available, KIR2DL5 carriers were at an increased risk of overall infection and viral infection (crude OR = 2.66; 95% CI 1.43, 4.92; P = 0.017 and crude OR = 2.31; 95% CI 1.15, 4.62; P = 0.017, respectively). After adjusting for methylprednisolone pulse and/or cyclophosphamide pulse therapy, KIR2DL5 carriers were at significantly greater risk of infectious events overall (adjusted OR = 2.45; 95% CI 1.24, 4.81; P = 0.0095). However, KIR2DL5 carriers were marginally associated with an increased risk of viral infectious events (adjusted OR = 2.03; 95% CI 0.94, 4.41; P = 0.0718). Conclusion. KIR2DL5 was significantly associated with a decreased risk of SLE as well as an increased risk of infectious events overall in SLE patients. Our data suggest a further role of KIRs in the pathogenesis of autoimmune diseases and infection.

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